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LSD and ketanserin and their impact on the human autonomic nervous system
Psychophysiology ( IF 3.7 ) Pub Date : 2021-03-27 , DOI: 10.1111/psyp.13822
Sebastian Olbrich 1 , Katrin H Preller 1 , Franz X Vollenweider 1
Affiliation  

The interest in lysergic acid diethylamide (LSD) has sparked again due to its supposed positive effects on psychopathological conditions. Yet, most research focuses on the actions of LSD on the central nervous system. The interaction with the autonomic nervous system (ANS) has been neglected so far. Therefore, the aim was to assess the effects of LSD and the serotonin 2A receptor antagonist ketanserin on the ANS as assessed by heart rate variability (HRV) measures and their correlation with subjective drug-induced effects in a randomized, placebo-controlled crossover trial. Thus, ANS activity was derived from electrocardiogram recordings after intake of placebo, LSD or ketanserin, and LSD by calculating R-peak-based measures of sympathetic and parasympathetic activity. Repeated measure ANOVA and partial correlation for HRV measures and subjective experience questionnaires were performed. LSD predominantly increased sympathetic activity, while ketanserin counteracted this effect on the ANS via an increase of parasympathetic tone. Sympathetic activity was positively and parasympathetic activity negatively associated with psychedelic effects of LSD. Furthermore, Placebo HRV measures predicted subjective experiences after LSD intake. The association between trait ANS activity and LSD-induced subjective experiences may serve as a candidate biomarker set for the effectiveness of LSD in the treatment of psychopathological conditions.

中文翻译:

LSD和酮色林及其对人体自主神经系统的影响

对麦角酸二乙胺 (LSD) 的兴趣再次引发了人们的兴趣,因为它被认为对精神病理学状况有积极影响。然而,大多数研究都集中在 LSD 对中枢神经系统的作用上。迄今为止,与自主神经系统 (ANS) 的相互作用一直被忽视。因此,目的是通过心率变异性 (HRV) 测量评估 LSD 和 5-羟色胺 2A 受体拮抗剂酮色林对 ANS 的影响,以及它们与随机、安慰剂对照交叉试验中主观药物诱导效应的相关性。因此,ANS 活动来源于服用安慰剂、LSD 或酮色林和 LSD 后的心电图记录,方法是计算基于 R 峰的交感神经和副交感神经活动的测量值。对 HRV 测量和主观体验问卷进行重复测量方差分析和偏相关。LSD 主要增加交感神经活动,而酮色林通过增加副交感神经张力来抵消这种对 ANS 的影响。交感神经活动与 LSD 的迷幻作用呈正相关,副交感神经活动呈负相关。此外,安慰剂 HRV 测量 LSD 摄入后预测的主观体验。特质 ANS 活动与 LSD 诱导的主观体验之间的关联可作为 LSD 在治疗精神病理学病症中有效性的候选生物标志物集。交感神经活动与 LSD 的迷幻作用呈正相关,副交感神经活动呈负相关。此外,安慰剂 HRV 测量 LSD 摄入后预测的主观体验。特质 ANS 活动与 LSD 诱导的主观体验之间的关联可作为 LSD 在治疗精神病理学病症中有效性的候选生物标志物集。交感神经活动与 LSD 的迷幻作用呈正相关,副交感神经活动呈负相关。此外,安慰剂 HRV 测量 LSD 摄入后预测的主观体验。特质 ANS 活动与 LSD 诱导的主观体验之间的关联可作为 LSD 在治疗精神病理学病症中有效性的候选生物标志物集。
更新日期:2021-06-01
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