Irisin is a hormone cleaved from fibronectin type-III domain-containing protein 5 in response to exercise and may be therapeutic in Alzheimer's disease (AD). Irisin is shown to repair damage caused by midlife cardiometabolic risk factors for AD (i.e., diabetes mellitus; hypertension), prevent neural amyloid beta aggregation and reduce neuroinflammation. However, there are no investigations of irisin's effect on AD-associated tauopathy in the brain. This study begins to address this gap in knowledge.

中文翻译：

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鸢尾素治疗可降低症状前雌性而非雄性 htau 小鼠海马中磷酸化 tau 的水平

鸢尾素是一种激素，由含有纤连蛋白 III 型结构域的蛋白质 5 对运动作出反应，可用于治疗阿尔茨海默病 (AD)。鸢尾素被证明可修复由 AD 的中年心脏代谢危险因素（即糖尿病；高血压）引起的损伤，防止神经淀粉样蛋白 β 聚集并减少神经炎症。然而，没有研究鸢尾素对大脑中 AD 相关 tau 病变的影响。这项研究开始解决这一知识差距。