Ecdysone receptor (EcR) is the primary regulator of the ecdysteroid signalling pathway, a critical pathway that directly links to moulting. In addition, EcR also regulates growth, development, reproduction and regeneration in crustaceans. However, there remains a huge gap of knowledge between the detailed structure and functional role(s) of crustacean EcR compared to that of insects. Motif and phylogenetic analyses of publicly available crustacean EcR proteins revealed the evolutionary relationship of EcR in this subphylum and highlighted its conserved characteristics among crustaceans. The role of EcR in the regulation of essential physiological processes in crustaceans including moulting, chitin synthesis, general growth and development, gonadal and maturation, and limb regeneration was discussed based on the available literature. This essential moult-related nuclear receptor could serve as a useful molecular indicator of moulting and gonadal maturation, as a potential target for pesticide production against parasitic crustacean species in the aquaculture industry, as well as valuable bioindicators of environmental stressors.

中文翻译：

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甲壳类蜕皮激素受体的最新进展：甲壳类水产养殖的当前知识和未来应用

蜕皮激素受体 (EcR) 是蜕皮激素信号通路的主要调节剂，这是直接与换羽相关的关键通路。此外，EcR 还调节甲壳类动物的生长、发育、繁殖和再生。然而，与昆虫相比，甲壳类 EcR 的详细结构和功能作用之间仍然存在巨大的知识差距。公开可用的甲壳类 EcR 蛋白的基序和系统发育分析揭示了 EcR 在该亚门中的进化关系，并突出了其在甲壳类动物中的保守特征。基于现有文献讨论了 EcR 在调节甲壳类动物基本生理过程中的作用，包括蜕皮、几丁质合成、一般生长和发育、性腺和成熟以及肢体再生。