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Controlled biointerfaces with biomimetic phosphorus-containing polymers
Science and Technology of Advanced Materials ( IF 5.5 ) Pub Date : 2021-05-28 , DOI: 10.1080/14686996.2021.1908095
Suphatra Hiranphinyophat 1 , Yasuhiko Iwasaki 2
Affiliation  

ABSTRACT

Phosphorus is a ubiquitous and one of the most common elements found in living organisms. Almost all molecules containing phosphorus in our body exist as analogs of phosphate salts or phosphoesters. Their functions are versatile and important, being responsible for forming the genetic code, cell membrane, and mineral components of hard tissue. Several materials inspired from these phosphorus-containing biomolecules have been recently developed. These materials have shown unique properties at the biointerface, such as nonfouling ability, blood compatibility, lubricity, mineralization induction capability, and bone affinity. Several unfavorable events occur at the interface of materials and living organisms because most of these materials have not been designed while taking host responses into account. These unfavorable events are directly linked to reducing functions and shorten the usable periods of medical devices. Biomimetic phosphorus-containing polymers can improve the reliability of materials in biological systems. In addition, phosphorus-containing biomimetic polymers are useful not only for improving the biocompatibility of material surfaces but also for adding new functions due to the flexibility in molecular design. In this review, we describe the recent advances in the control of biointerfacial phenomena with phosphorus-containing polymers. We especially focus on zwitterioninc phosphorylcholine polymers and polyphosphoesters.



中文翻译:

具有仿生含磷聚合物的受控生物界面

摘要

磷是一种无处不在的元素,也是生物体中最常见的元素之一。我们体内几乎所有含磷的分子都以磷酸盐或磷酸酯的类似物形式存在。它们的功能多样且重要,负责形成遗传密码、细胞膜和硬组织的矿物质成分。最近开发了几种受这些含磷生物分子启发的材料。这些材料在生物界面上显示出独特的特性,例如防污能力、血液相容性、润滑性、矿化诱导能力和骨亲和力。在材料和生物体的界面上会发生一些不利事件,因为这些材料中的大多数都没有在设计时考虑到宿主的反应。这些不利事件与降低医疗器械的功能和缩短使用寿命直接相关。仿生含磷聚合物可以提高生物系统材料的可靠性。此外,由于分子设计的灵活性,含磷的仿生聚合物不仅可用于改善材料表面的生物相容性,还可用于添加新功能。在这篇综述中,我们描述了用含磷聚合物控制生物界面现象的最新进展。我们特别关注两性离子磷酸胆碱聚合物和多磷酸酯。含磷仿生聚合物不仅可用于提高材料表面的生物相容性,而且由于分子设计的灵活性,还可用于添加新功能。在这篇综述中,我们描述了用含磷聚合物控制生物界面现象的最新进展。我们特别关注两性离子磷酸胆碱聚合物和多磷酸酯。含磷仿生聚合物不仅可用于提高材料表面的生物相容性,而且由于分子设计的灵活性,还可用于添加新功能。在这篇综述中,我们描述了用含磷聚合物控制生物界面现象的最新进展。我们特别关注两性离子磷酸胆碱聚合物和多磷酸酯。

更新日期:2021-05-28
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