In this review article, we describe the application, reactivity and synthesis of isoxazole derivatives, more specifically, the application, reactivity, and synthesis of 3,5-disubstituted, 3,4- disubstituted, and 3,4,5-trisubstituted isoxazole using the green method. We review the application of isoxazole in material science, agriculture and pharmaceutical. In material science, isoxazole is used as a photochromic, electrochemical probe for Cu²⁺ and, given its optical properties, in dye-sensitized solar cells, high energy material and liquid crystal. In agriculture, isoxazole is used as an insecticide for managing Callosobruchus chinensis, Acaricidal activity against T. cinnabarinus, and herbicidal activities of 2-cyanoacrylates containing isoxazole. In pharmaceutical, isoxazole shows anticancer, antituberculosis, anti-inflammatory, and acetylcholinesterase inhibitors. Further, we describe various reactions of isoxazole such as ring opens, bromination and iodination, thioynol ethers, intramolecular SEAr reaction, arylation, cycloaddition and photocycloaddition, photoisomerization, Domino transformation of isoxazoles to 2,4-dicarbonyl pyrroles and rearrangement. We also describe the synthesis of 3,5-disubstituted, 3,4-disubstituted and 3,4,5-trisubstituted isoxazole using different methods.

在这篇综述文章中，我们描述了异恶唑衍生物的应用，反应性和合成，更具体地说，使用以下方法描述了3,5-二取代，3,4-二取代和3,4,5-三取代异恶唑的应用，反应性和合成绿色方法。我们综述了异恶唑在材料科学，农业和制药领域的应用。在材料科学中，异恶唑用作Cu ²⁺的光致变色电化学探针鉴于其光学特性，它可用于染料敏化太阳能电池，高能材料和液晶。在农业中，异恶唑用作杀虫剂，用于处理中华Call，对朱砂毛虫的杀螨活性以及含有异恶唑的2-氰基丙烯酸酯的除草活性。在药物中，异恶唑显示出抗癌，抗结核，抗炎和乙酰胆碱酯酶抑制剂。此外，我们描述了异恶唑的各种反应，例如开环，溴化和碘化，硫代炔醇醚，分子内SEAr反应，芳基化，环加成和光环加成，光异构化，异恶唑的多米诺转化为2,4-二羰基吡咯和重排。我们还描述了3,5-二取代，3,4-二取代和3,4的合成，