Nowadays, carbon-based nanostructure materials are regarded as promising carriers for drug delivery to improve the effective treatment of diseases. The formation of covalent and noncovalent molecular bonds can be used for surface modification of nano-carriers in order to manipulate their toxicity, water solubility, and cellular internalization. Graphene and its derivatives have shown important potential in drug delivery systems. Among different graphene derivatives, Graphene Oxide (GO) is the most extensively used derivative. GO sheets have possessed certain oxygen functional groups including carboxylic acid groups at the edges, epoxy and hydroxyl groups on the basal planes. The oxygen groups on the surface of GO sheets enhance their capabilities for functionalization with chemical and bioactive molecules. In this review, we highlight the recent researches about the effect of reactive sites on the surface of GO and its derivatives in drug delivery systems. Therefore, the application of GO and its derivatives have been discussed as a delivery system in cancer treatment, gene therapy, and combination therapy, followed by discussions on their related issues. Finally, the review will provide a future perspective to the applications of GO-based materials as part of drug delivery systems, and may open up new viewpoints to motivate broader interests across these interdisciplinary fields.

如今，碳基纳米结构材料被认为是用于药物输送以改善疾病有效治疗的有前途的载体。共价和非共价分子键的形成可用于纳米载体的表面修饰，以控制其毒性，水溶性和细胞内在化。石墨烯及其衍生物在药物递送系统中显示出重要的潜力。在不同的石墨烯衍生物中，氧化石墨烯（GO）是使用最广泛的衍生物。GO片材具有某些氧官能团，包括边缘的羧酸基团，在基面上的环氧基和羟基。GO片材表面的氧基团增强了其被化学和生物活性分子官能化的能力。在这篇评论中，我们重点介绍了关于GO及其衍生物在药物递送系统中表面活性部位的作用的最新研究。因此，已经讨论了GO及其衍生物作为递送系统在癌症治疗，基因治疗和联合治疗中的应用，随后讨论了它们的相关问题。最后，本综述将为基于GO的材料作为药物输送系统的一部分的应用提供未来的观点，并可能开辟新的观点，以激发这些跨学科领域的广泛兴趣。接下来是有关其相关问题的讨论。最后，本综述将为基于GO的材料作为药物输送系统的一部分的应用提供未来的观点，并可能开辟新的观点，以激发这些跨学科领域的广泛兴趣。接下来是有关其相关问题的讨论。最后，本综述将为基于GO的材料作为药物输送系统的一部分的应用提供未来的观点，并可能开辟新的观点，以激发这些跨学科领域的广泛兴趣。