Pornographic addiction refers to an addiction model associated with compulsive and repeated use of pornographic material. Whether the use of pornography may indeed become addictive remains a matter of debate. The current study investigated whether compulsive pornography use (CPU) is accompanied by reduced D2/3 receptor availability in the striatum and frontal hypofunctionality. Male subjects between 18 and 50 years of age with and without CPU were recruited using online and newspaper advertisements. Questionnaires were used to the assess the severity of compulsive pornography use (CIUS) and symptoms of depression, impulsivity and sensation seeking. Dopaminergic imaging was performed using [11C]-raclopride PET. Striatal binding potentials (BPND) and regional frontal cerebral influx values (R1) of [11C]-raclopride were calculated. Arterial Spin Labeling (ASL) MRI was performed to assess regional cerebral blood flow. No group differences between striatal BPND's of [11C]-raclopride in subjects with (n = 15) and without (n = 10) CPU were detected. In CPU subjects, no correlation was found between the CIUS score and striatal BPND's. Cerebral R1 values in frontal brain regions and cerebral blood flow measurements did not differ between groups. The current study fails to provide imaging support for sharing similar neurobiological alterations as previously has been reported in other addictive modalities.

色情成瘾是指与强迫和重复使用色情材料相关的成瘾模型。使用色情内容是否真的会上瘾仍然是一个有争议的问题。目前的研究调查了强迫性色情使用（CPU）是否伴随着纹状体中 D2/3 受体可用性的降低和额叶功能减退。使用在线和报纸广告招募了年龄在 18 至 50 岁之间有和没有 CPU 的男性受试者。问卷用于评估强迫色情使用（CIUS）的严重程度以及抑郁、冲动和寻求感觉的症状。使用 [11C]-雷氯必利 PET 进行多巴胺能成像。计算了 [11C]-雷氯必利的纹状体结合电位 (BPND) 和区域额脑流入值 (R1)。进行动脉自旋标记 (ASL) MRI 以评估局部脑血流。[11C]-雷氯必利的纹状体 BPND 在患有 (检测到n  = 15) 和没有 ( n  = 10) CPU。在 CPU 受试者中，未发现 CIUS 评分与纹状体 BPND 之间的相关性。额叶区域的脑 R1 值和脑血流测量值在各组之间没有差异。目前的研究未能为共享类似的神经生物学改变提供成像支持，正如以前在其他成瘾方式中报道的那样。