Abstract

Background

Alzheimer’s disease (AD) is a neurodegenerative disease that causes a gradual loss of cognitive functions and limits daily activities performance. Early diagnosis of AD is essential to start timely treatment. This study aimed to validate the Uniform Data Set neuropsychological battery version 3.0 (UDS 3.0) in a Colombian cohort.

Methods

This study is a cross-sectional type, consecutive, incidental, with 143 persons, divided into two groups: 48 diagnosed AD cases and 95 healthy controls, between the ages of 50 and 80+, and between 1 and 19+ years of education.

Results

The results indicate differences between the control group and the AD group in most battery tests. A significant correlation was found between the Montreal Cognitive Assessment (MoCA), Multilingual Naming Test (MINT), Craft Story, Benson Figure Test, P-word and F-word Phonemic Fluency Test, and their respective reference tests. Cutoff points were found based on the Youden index for each sub-test. The results indicate that all sub-tests are above the reference line of the ROC curve.

Conclusion

The use of the UDS 3.0 in Colombia would help improving clinical diagnostic routes because of its high accuracy and high correlation with tests that measure general impairment; it has good sensitivity and specificity, and it can be a useful tool for AD.

中文翻译：

---

UDS 3.0 神经心理电池在哥伦比亚阿尔茨海默病队列中的诊断准确性

摘要

背景

阿尔茨海默病 (AD) 是一种神经退行性疾病，会导致认知功能逐渐丧失并限制日常活动表现。AD的早期诊断对于开始及时治疗至关重要。本研究旨在验证哥伦比亚队列中的统一数据集神经心理学电池版本 3.0 (UDS 3.0)。

方法

本研究为横断面类型、连续性、偶然性，143 人，分为两组：48 名诊断为 AD 的病例和 95 名健康对照，年龄在 50 至 80 岁之间，教育在 1 至 19 年以上。

结果

结果表明，在大多数电池测试中，对照组和 AD 组之间存在差异。在蒙特利尔认知评估 (MoCA)、多语言命名测试 (MINT)、Craft Story、Benson Figure 测试、P-word 和 F-word 音素流利度测试以及它们各自的参考测试之间发现了显着相关性。根据每个子测试的约登指数找到截止点。结果表明，所有子测试均高于 ROC 曲线的参考线。

结论

在哥伦比亚使用 UDS 3.0 将有助于改进临床诊断途径，因为它具有高准确性和与测量一般损伤的测试的高度相关性；它具有良好的敏感性和特异性，可以作为AD的有用工具。