Cadmium (Cd) is a highly toxic, nonessential heavy metal that has been associated with a variety of toxicological effects in both humans and animals. The main objective of this research was to investigate bioaccumulation, intestinal apoptosis, and digestive dysfunction effects of waterborne cadmium in the intestine of crucian carp Carassius auratus gibelio. Fish were exposed to 0, 100, and 500 μg/L waterborne Cd for 4 weeks, and the results showed that Cd accumulation in the intestine was significantly increased as Cd concentration increased. The intestinal structure was severely damaged, including mucosal fold length decreased, the rough endoplasmic reticulum underwent marked swelling and indistinct, and the intestinal microvilli transformed or nearly disappeared. The activities of intestinal apoptosis enzymes (Caspases 3, Caspases 8, and Caspases 9) and apoptosis rate of enterocyte cells were significantly elevated in 500 μg/L waterborne Cd group, activities of digestive enzymes (amylase and protease) were significantly decreased by 500 μg/L waterborne Cd. Overall, our results demonstrated that waterborne Cd exposure could increase Cd bioaccumulation in the intestine and destroy the intestinal digestibility of crucian carp, which in turn led to the occurrence of cell apoptosis.

镉（Cd）是一种剧毒的，非必需的重金属，已与人类和动物的多种毒理作用有关。这项研究的主要目的是探讨生物蓄积性，肠细胞凋亡，并在鲫鱼肠道水性镉的消化功能障碍的影响异育银鲫。将鱼暴露于0、100和500μg/ L的水中Cd中暴露4周，结果表明，随着Cd浓度的增加，小肠中Cd的积累显着增加。肠道结构严重受损，包括粘膜折叠长度减少，粗糙的内质网明显肿胀和模糊，肠道微绒毛转变或几乎消失。500μg/ L水性Cd组肠道凋亡酶（Caspases 3，Caspases 8和Caspases 9）的活性和肠细胞的凋亡率显着提高，消化酶（淀粉酶和蛋白酶）的活性显着降低500μg / L水性Cd。全面的，