Contact lens materials have undergone significant changes over the past 20 years, particularly with respect to the introduction of silicone hydrogel materials. Whilst this development addressed hypoxic issues, other important areas relating to contact lens success, notably comfort, require further research.

Contact lens wettability remains a crucially important part of biocompatibility. Contact lenses can be made more wettable by incorporation of surfactants into blister packs, internal wetting agents, surface treatments or care solutions. However, there remains no clear association between contact lens wettability and comfort, making it challenging to determine the potential for these approaches to be of significant clinical benefit. Most contact lenses are used on a daily wear, reusable basis, which requires them to be disinfected when not worn. The ideal disinfecting solution would also improve comfort during wear. However, balancing these requirements with other factors, including biocompatibility, remains a challenge. Soft lens materials invariably take up and subsequently release certain components of disinfecting solutions onto the ocular surface. This may affect tear film stability and the normal ocular microbiome, and further research is needed in this area to determine whether this has any affect on comfort. Finally, contact lens materials sorb components of the tear film, and these interactions are complex and may change the biochemistry of the tear film, which in turn may affect their comfort.

In conclusion, the interaction between lens materials, tear film and disinfection solution plays an important role in the biocompatibility of lenses. However, the exact role and whether this can be altered to improve biocompatibility and comfort during wear remains debatable. This report summarises the best available evidence to examine this complex relationship and the opportunities for practitioners to enhance in-eye comfort of contemporary lenses, along with providing suggestions for areas of study that may provide further information on this topic.

在过去的 20 年中，隐形眼镜材料发生了重大变化，尤其是在引入硅水凝胶材料方面。虽然这一发展解决了缺氧问题，但与隐形眼镜成功相关的其他重要领域，特别是舒适度，需要进一步研究。

隐形眼镜润湿性仍然是生物相容性的一个至关重要的部分。通过在泡罩包装、内部润湿剂、表面处理或护理液中加入表面活性剂，可以使隐形眼镜具有更好的润湿性。然而，隐形眼镜润湿性和舒适性之间仍然没有明确的关联，这使得确定这些方法具有显着临床益处的潜力具有挑战性。大多数隐形眼镜都是日常佩戴、可重复使用的，这要求在不佩戴时对其进行消毒。理想的消毒解决方案还可以提高佩戴时的舒适度。然而，平衡这些要求与其他因素，包括生物相容性，仍然是一个挑战。软镜片材料总是吸收并随后将消毒液的某些成分释放到眼表上。这可能会影响泪膜稳定性和正常的眼部微生物群，该领域需要进一步研究以确定这是否对舒适度有任何影响。最后，隐形眼镜材料会吸附泪膜的成分，这些相互作用很复杂，可能会改变泪膜的生物化学，进而影响其舒适度。

总之，镜片材料、泪膜和消毒液之间的相互作用对镜片的生物相容性起着重要作用。然而，确切的作用以及是否可以改变它以提高佩戴过程中的生物相容性和舒适度仍然存在争议。本报告总结了研究这种复杂关系的最佳可用证据，以及从业者提高现代镜片眼内舒适度的机会，同时为可能提供有关该主题的进一步信息的研究领域提供建议。