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Novel roles of Tsukushi in signaling pathways and multiple disease processes
Biofactors ( IF 6 ) Pub Date : 2021-03-23 , DOI: 10.1002/biof.1723
Xia Deng 1 , Yanyan Li 2 , Chang Guo 1 , Zhicong Zhao 1 , Guoyue Yuan 1
Affiliation  

Tsukushi (TSK), a newly identified hepatokine, is a member of the small leucine-rich proteoglycans (SLRPs) family. TSK was originally isolated and identified in the lens of the chicken. Preliminary research on TSK has focused on its role in various physiological processes such as growth and development, wound healing, and cartilage formation. In recent years, the role of TSK in regulating cell signaling pathways, cell proliferation, and differentiation has been studied. In addition, the research has gradually expanded to the fields of glycolipid metabolism and energy balance. This article briefly reviews the role of TSK in the physiological and pathological process.

中文翻译:

Tsukushi 在信号通路和多种疾病过程中的新作用

Tsukushi (TSK) 是一种新发现的肝因子,是富含亮氨酸的小蛋白聚糖 (SLRP) 家族的成员。TSK最初是在鸡的晶状体中分离和鉴定的。TSK 的初步研究集中在其在各种生理过程中的作用,如生长发育、伤口愈合和软骨形成。近年来,人们研究了 TSK 在调节细胞信号通路、细胞增殖和分化中的作用。此外,研究也逐渐扩展到糖脂代谢和能量平衡等领域。本文简要回顾了TSK在生理和病理过程中的作用。
更新日期:2021-03-23
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