Abstract

Purpose

To investigate the association between hydroxychloroquine (HCQ) use and macular pigment optic densitometry (MPOD) abnormalities.

Materials and Methods

Fifty patients that have been receiving HCQ treatment and forty-eight control subjects were randomly selected from patients with no visual impairment with similar age and gender. All participants underwent detailed ophthalmologic examination including fundus photography, fundus autofluorescence, optic coherence tomography, and visual field analysis. Macular pigment optical density (MPOD) was measured by fundus reflectometry using one-wavelength reflection method. Patients with ongoing HCQ treatment formed the HCQ group and healthy subjects formed the control group.

Results

Mean age was 50.9 ± 7.9 and 47.9 ± 9.4 years in the HCQ and controls groups respectively (p = 0.098) Between the groups, there is no significant difference in central foveal thickness and mean deviation and pattern standard deviation in the visual field analysis. Parafoveal hyper fluorescence lesions were detected in 5 (%10) patients. Choroidal thickness was significantly decreased in the HCQ group (p = 0.001). Maximum and mean MPOD outcomes were significantly lower in the HCQ group (p = 0.005, p = 0.003, respectively). Between the groups, there was no difference in mean MPOD volume and MPOD area.

Conclusions

Patients with HCQ use have reduced MPOD. Further studies are required investigating the sensitivity and specificity of MPOD in detecting initial retinal changes in patients with HCQ use.

中文翻译：

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黄斑色素光密度测定在羟氯喹使用中的变化

摘要

目的

研究羟氯喹 (HCQ) 使用与黄斑色素光密度测定 (MPOD) 异常之间的关联。

材料和方法

从年龄和性别相近的无视力障碍患者中随机选择 50 名接受 HCQ 治疗的患者和 48 名对照受试者。所有参与者都接受了详细的眼科检查，包括眼底照相、眼底自发荧光、光学相干断层扫描和视野分析。黄斑色素光密度（MPOD）是通过眼底反射法使用单波长反射法测量的。正在接受 HCQ 治疗的患者构成 HCQ 组，健康受试者构成对照组。

结果

HCQ 组和对照组的平均年龄分别为 50.9 ± 7.9 和 47.9 ± 9.4 岁 ( p  = 0.098) 各组之间，视野分析中的中央凹厚度和平均偏差和模式标准偏差没有显着差异。在 5 (%10) 名患者中检测到旁中心凹高荧光病变。HCQ 组的脉络膜厚度显着降低（p  = 0.001）。HCQ 组的最大和平均 MPOD 结果显着降低（分别为p  = 0.005、p  = 0.003）。在各组之间，平均 MPOD 体积和 MPOD 面积没有差异。

结论

使用 HCQ 的患者 MPOD 降低。需要进一步研究 MPOD 在检测使用 HCQ 患者的初始视网膜变化方面的敏感性和特异性。