Journal of Comparative Pathology ( IF 0.8 ) Pub Date : 2021-03-23 , DOI: 10.1016/j.jcpa.2021.02.005 Sandro Mazzariol 1 , Cinzia Centelleghe 1 , Antonio Petrella 2 , Federica Marcer 3 , Matteo Beverelli 2 , Cristina E Di Francesco 4 , Gabriella Di Francesco 5 , Ludovica Di Renzo 5 , Giovanni Di Guardo 4 , Tania Audino 6 , Letizia Tripodi 6 , Cristina Casalone 6
The Mediterranean monk seal (Monachus monachus) is the rarest species of pinniped in the world. Necropsy of a Mediterranean monk seal pup that stranded alive on the southern Adriatic Italian coast and died a few hours later revealed co-infection by cetacean morbillivirus (CeMV) and Toxoplasma gondii. Pathological lesions included a multifocal, moderate to severe, necrotizing myocarditis and a diffuse, chronic, moderate interstitial pneumonia with bronchial and bronchiolar epithelial hyperplasia. Lesions of atypical necrotizing arteritis were seen in the aorta and major pulmonary arteries in association with the presence T. gondii organisms. Severe haemorrhagic foci and lesions of non-suppurative meningoencephalitis, together with the presence of protozoal cysts, were seen in the brain. Co-infection of CeMV and T. gondii has not been previously reported in monk seals. The vascular lesions found in this animal can be considered atypical because they have not been reported in other terrestrial or marine mammal species. The disseminated toxoplasmosis associated with the unusual vascular and haemorrhagic brain lesions could be related to the immunosuppressive effects of CeMV infection.
中文翻译:
地中海僧海豹 (Monachus monachus) 幼崽的非典型弓形虫病
地中海僧海豹(Monachus monachus)是世界上最稀有的鳍足类动物。一只地中海僧海豹幼崽活活搁浅在意大利亚得里亚海南部海岸,几小时后死亡,尸检结果显示,它同时感染了鲸类麻疹病毒 (CeMV) 和弓形虫。病理病变包括多灶性、中度至重度坏死性心肌炎和弥漫性、慢性、中度间质性肺炎,伴有支气管和细支气管上皮增生。在主动脉和主要肺动脉中观察到非典型坏死性动脉炎的病变,并伴有弓形虫的存在生物体。在大脑中观察到严重的出血病灶和非化脓性脑膜脑炎病变,以及原生动物囊肿的存在。CeMV 和刚地弓形虫的共感染以前没有在僧海豹中报道过。在这种动物身上发现的血管病变可以被认为是非典型的,因为在其他陆地或海洋哺乳动物物种中没有报道过这种病变。与异常血管和出血性脑损伤相关的播散性弓形虫病可能与 CeMV 感染的免疫抑制作用有关。