The prevalence of childhood B cell acute lymphoblastic leukemia (B-ALL) is increasing, particularly in developed countries. There is no clear explanation for this increment, but recent data suggest that, besides genetic predisposition, stress in the immune system (e.g., an infection) might have an important role in B-ALL leukemogenesis. Here, we speculate on how this knowledge might impact B-ALL prevention strategies.

中文翻译：

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预防儿童B细胞白血病的机会性免疫窗

儿童期B细胞急性淋巴细胞白血病（B-ALL）的患病率正在上升，尤其是在发达国家。对于这种增加没有明确的解释，但是最近的数据表明，除了遗传易感性之外，免疫系统中的压力（例如感染）可能在B-ALL白血病发生中起重要作用。在这里，我们推测这些知识如何影响B-ALL预防策略。