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Adenosine and adenosine receptor-mediated action in coronary microcirculation
Basic Research in Cardiology ( IF 9.5 ) Pub Date : 2021-03-23 , DOI: 10.1007/s00395-021-00859-7
Ying Zhang 1 , Bernhard Wernly 2 , Xin Cao 1 , S Jamal Mustafa 3 , Yong Tang 1, 4 , Zhichao Zhou 5
Affiliation  

Adenosine is an ubiquitous extracellular signaling molecule and plays a fundamental role in the regulation of coronary microcirculation through activation of adenosine receptors (ARs). Adenosine is regulated by various enzymes and nucleoside transporters for its balance between intra- and extracellular compartments. Adenosine-mediated coronary microvascular tone and reactive hyperemia are through receptors mainly involving A2AR activation on both endothelial and smooth muscle cells, but also involving interaction among other ARs. Activation of ARs further stimulates downstream targets of H2O2, KATP, KV and KCa2+ channels leading to coronary vasodilation. An altered adenosine-ARs signaling in coronary microcirculation has been observed in several cardiovascular diseases including hypertension, diabetes, atherosclerosis and ischemic heart disease. Adenosine as a metabolite and its receptors have been studied for its both therapeutic and diagnostic abilities. The present review summarizes important aspects of adenosine metabolism and AR-mediated actions in the coronary microcirculation.



中文翻译:

腺苷和腺苷受体介导的冠状动脉微循环作用

腺苷是一种普遍存在的细胞外信号分子,通过激活腺苷受体 (ARs) 在调节冠状动脉微循环中发挥重要作用。腺苷受各种酶和核苷转运蛋白的调节,以实现其在细胞内和细胞外区室之间的平衡。腺苷介导的冠状动脉微血管张力和反应性充血是通过受体,主要涉及内皮细胞和平滑肌细胞上的 A 2AR激活,但也涉及其他 AR 之间的相互作用。ARs 的激活进一步刺激 H 2 O 2、K ATP、K V和 K Ca2+的下游靶标导致冠状动脉扩张的通道。在包括高血压、糖尿病、动脉粥样硬化和缺血性心脏病在内的几种心血管疾病中观察到冠状动脉微循环中腺苷-ARs信号的改变。腺苷作为一种代谢物及其受体已针对其治疗和诊断能力进行了研究。本综述总结了冠状动脉微循环中腺苷代谢和 AR 介导的作用的重要方面。

更新日期:2021-03-23
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