ABSTRACT

This umbrella review summarizes the available meta-analyses elucidating the effects of maternal pesticide exposure on adverse health outcomes in children particularly the risk of childhood cancer. A literature search was conducted on PubMed and Scopus with 10-years temporal restriction and with search terms of (‘pesticides’) and (‘maternal’ or ‘pregnancy’ or ‘gestational’ or ‘perinatal’ or ‘children’ or ‘infants’ or ‘birth weight’ or ‘gestational age’ or ‘cancer’ or ‘tumor’ or ‘malignancy’ or ‘carcinoma’) and (‘meta-analysis’ or ‘systematic review’). Using relative risk estimates, e.g., odds ratio (OR), relative risk (RR), ß coefficients, and 95% confidence interval (CI) as a prerequisite for inclusion/exclusion criteria a total of 19 eligible meta-analyses were included. The results showed that maternal domestic/occupational pesticide exposure increases the risk for childhood leukaemia. The overall OR regarding the risk of pesticide exposure and leukaemia was 1.23 to 1.57 with heterogeneity I² values that varied between 12.9% and 73%. Some studies found that exposure to dichlorodiphenyldichloroethylene (p,p´-DDE) and polychlorinated biphenyls (PCB-153) pesticides appears to decrease infant birth weight to some extent [p,p´-DDE (ß = −0.007 to −0.008)] and [PCB-153 (ß = −0.15 to −0.17)]Needing more studies on this relationship, our study found that pesticide exposure is a risk factor for leukaemia in children.

摘要

这篇综述总结了现有的荟萃分析，阐明了母体农药暴露对儿童不良健康结果的影响，尤其是儿童癌症风险。在 PubMed 和 Scopus 上进行了具有 10 年时间限制的文献检索，检索词为 ('pesticides') 和 ('maternal' or 'pregnancy' or 'gestational' or 'perinatal' or 'children' or 'infants'或“出生体重”或“胎龄”或“癌症”或“肿瘤”或“恶性肿瘤”或“癌”）和（“荟萃分析”或“系统评价”）。使用相对风险估计，例如优势比 (OR)、相对风险 (RR)、β 系数和 95% 置信区间 (CI) 作为纳入/排除标准的先决条件，共纳入 19 项符合条件的荟萃分析。结果表明，母亲的家庭/职业农药暴露会增加儿童白血病的风险。关于农药暴露和白血病风险的总体 OR 为 1.23 至 1.57，异质性 I^{2 个}值在 12.9% 和 73% 之间变化。一些研究发现，暴露于二氯二苯二氯乙烯 (p,p´-DDE) 和多氯联苯 (PCB-153) 农药似乎会在一定程度上降低婴儿出生体重 [p,p´-DDE (ß = -0.007 至 -0.008)]和 [PCB-153 (ß = -0.15 to -0.17)]需要对这种关系进行更多研究，我们的研究发现农药暴露是儿童白血病的危险因素。