Objective:Agenesis of the corpus callosum (AgCC) is associated with a range of cognitive deficits, including mild to moderate problems in higher order executive functions evident in neuropsychological assessments. Previous research has also suggested a lack of self-awareness in persons with AgCC.Method:We investigated daily executive functioning and self-awareness in 36 individuals with AgCC by analyzing self-ratings on the Behavior Rating Inventory of Executive Function-Adult Version (BRIEF-A), as well as ratings on the same instrument from close relatives. Discrepancies between self- and informant-ratings were compared to the normative sample and exploratory analyses examined possible moderating effects of participant and informant characteristics.Results:Significant deficiencies were found in the Behavioral Regulation and Metacognitive indices for both the self and informant results, with elevated frequency of metacognition scores in the borderline to clinical range. Informants also endorsed elevated frequency of borderline to clinically significant behavioral regulation scores. The proportion of AgCC participants whose self-ratings indicated less metacognitive impairment than informant-ratings was greater than in the normative sample. Self-ratings of behavioral regulation impairment decreased with age and informant-ratings of metacognition were higher in males than females.Conclusions:These findings provide evidence that individuals with AgCC experience mild to moderate executive functioning problems in everyday behavior which are observed by others. Results also suggest a lack of self-understanding or insight into the severity of these problems in the individuals with AgCC, particularly with respect to their metacognitive functioning.

中文翻译：

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胼胝体发育不全的日常执行功能和自我意识

目的：胼胝体发育不全（AgCC）与一系列认知缺陷有关，包括神经心理学评估中明显的高级执行功能的轻度至中度问题。先前的研究还表明，AgCC 患者缺乏自我意识。方法：我们通过分析成人版执行功能行为评定量表 (BRIEF) 的自我评定，调查了 36 名 AgCC 患者的日常执行功能和自我意识。 -A)，以及近亲对同一乐器的评级。将自我评价和线人评价之间的差异与规范样本进行比较，探索性分析检查了参与者和线人特征的可能调节作用。结果：在自我和知情人结果的行为调节和元认知指数中发现了显着缺陷，元认知评分的频率升高到临床范围的边缘。线人还认可临床显着行为调节分数的临界频率升高。AgCC 参与者的自评表明元认知障碍比知情人评分低的比例高于标准样本。行为调节障碍的自我评价随着年龄的增长而下降，男性对元认知的评价高于女性。结论：这些研究结果提供了证据，表明 AgCC 个体在日常行为中经历了其他人观察到的轻度至中度执行功能问题。