Objective

Previous studies have revealed different neuroimaging features between melancholic and non-melancholic major depressive disorder (MDD). However, homotopic connectivity of melancholic and non-melancholic MDD remains unknown. The present study aimed to explore common and distinct homotopic connectivity patterns of melancholic and non-melancholic MDD and their associations with clinical characteristics.

Methods

Sixty-four patients with MDD and thirty-two healthy controls were scanned by resting-state functional magnetic resonance imaging (fMRI). Voxel-mirrored homotopic connectivity (VMHC) and pattern classification were applied to analyze the imaging data.

Results

Relative to healthy controls, melancholic patients displayed decreased VMHC in the fusiform gyrus, posterior cingulate cortex (PCC), superior occipital gyrus (SOG), postcentral gyrus and precentral/postcentral gyrus, and non-melancholic patients displayed decreased VMHC in the PCC. Compared with non-melancholic patients, melancholic patients displayed reduced VMHC in the precentral gyrus and precentral/postcentral gyrus. Support vector machine (SVM) results exhibited VMHC in the precentral gyrus could distinguish melancholic patients from non-melancholic patients with more than 0.6 for specificity, sensitivity and accuracy.

Conclusion

The study demonstrated common and distinct homotopic connectivity patterns in melancholic and non-melancholic patients. Decreased VMHC in the PCC may be a state-related change for depression, and reduced VMHC in the precentral gyrus and postcentral gyrus may be a distinctive neurobiological feature for melancholic MDD. VMHC in precentral gyrus might be served as potential imaging markers to discriminate melancholic patients from non-melancholic MDD.

中文翻译：

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忧郁症和非忧郁症患者的同位异性同质连通性改变

客观的

先前的研究揭示了忧郁症和非忧郁症的主要抑郁症（MDD）之间的神经影像学特征不同。然而，忧郁和非忧郁MDD的同位连接仍然未知。本研究旨在探讨忧郁和非忧郁MDD的常见和独特的同位点连接模式及其与临床特征的关联。

方法

通过静止状态功能磁共振成像（fMRI）对64例MDD患者和32例健康对照者进行了扫描。体素镜像同位连接性（VMHC）和模式分类被用于分析成像数据。

结果

相对于健康对照，忧郁症患者的梭状回，后扣带回皮层（PCC），枕后回（SOG），中央后回和中央/中央后回回的VMHC降低，非忧郁症的患者在PCC的VMHC降低。与非忧郁症患者相比，忧郁症患者的中央前回和中央前/中央后回的VMHC降低。支持向量机（SVM）结果显示，中央前回的VMHC可以区分忧郁症患者和非忧郁症患者，其特异性，敏感性和准确性均超过0.6。

结论

该研究证明了忧郁症患者和非忧郁症患者常见且独特的同位异体连接模式。PCC中VMHC的减少可能是与抑郁有关的状态变化，而中央前回和中央后回的VMHC减少可能是忧郁MDD的独特神经生物学特征。中央前回中的VMHC可以作为潜在的影像学标志物，将忧郁症患者与非忧郁症的MDD进行区分。