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Lactate/albumin ratio is more effective than lactate or albumin alone in predicting clinical outcomes in intensive care patients with sepsis
Scandinavian Journal of Clinical and Laboratory Investigation ( IF 2.1 ) Pub Date : 2021-03-20 , DOI: 10.1080/00365513.2021.1901306
Esra Cakir 1 , Isil Ozkocak Turan 1
Affiliation  

Abstract

This study aimed to compare the value of lactate, albumin, and lactate/albumin ratio for the prediction of mortality in sepsis patients. Patients admitted to the intensive care unit (ICU) due to sepsis between January 2016 and January 2019 were evaluated retrospectively. Lactate, albumin, and lactate/albumin ratio values were compared between surviving and non-surviving patients and their predictive value for mortality was evaluated. A total of 1136 sepsis patients admitted to the ICU were included in the study. The mortality rate was 42.7% (485/1136 patients). In ROC analysis for mortality prediction, the area under the curve and optimal cut-off values were 0.816 and >2.2 mmol/L for lactate, 0.812 and ≤26 g/L for albumin, and 0.869 and >0.71 for lactate/albumin ratio, respectively. Our analysis of lactate, albumin, and lactate/albumin ratio in the largest patient sample to date showed that lactate/albumin ratio was a stronger parameter than lactate or albumin alone in predicting mortality among sepsis patients in the ICU. Lactate/albumin ratio is an easily obtained parameter with potential value for critically ill patients.



中文翻译:

乳酸/白蛋白比在预测重症监护脓毒症患者的临床结果方面比单独使用乳酸或白蛋白更有效

摘要

本研究旨在比较乳酸、白蛋白和乳酸/白蛋白比值在预测脓毒症患者死亡率方面的价值。回顾性评估了 2016 年 1 月至 2019 年 1 月期间因脓毒症入住重症监护病房 (ICU) 的患者。比较存活和非存活患者的乳酸、白蛋白和乳酸/白蛋白比值,并评估它们对死亡率的预测价值。该研究共纳入 1136 名入住 ICU 的脓毒症患者。死亡率为 42.7%(485/1136 名患者)。在死亡率预测的 ROC 分析中,乳酸的曲线下面积和最佳临界值分别为 0.816 和 >2.2 mmol/L,白蛋白为 0.812 和 ≤26 g/L,乳酸/白蛋白比率为 0.869 和 >0.71,分别。我们对乳酸、白蛋白、迄今为止最大的患者样本中的乳酸/白蛋白比值表明,在预测 ICU 脓毒症患者的死亡率方面,乳酸/白蛋白比值是比单独使用乳酸或白蛋白更强的参数。乳酸/白蛋白比率是一个容易获得的参数,对危重患者具有潜在价值。

更新日期:2021-05-03
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