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Controversy: For or against thyroid lobectomy in > 1 cm differentiated thyroid cancer?
Annales d'Endocrinologie ( IF 3.1 ) Pub Date : 2021-03-20 , DOI: 10.1016/j.ando.2021.03.004
Fabrice Menegaux 1 , Jean-Christophe Lifante 2
Affiliation  

In this controversy article, the respective advantages of lobectomy vs. total thyroidectomy in differentiated thyroid cancers are argued. The authors conclude that lobectomy has the same oncological prognosis as thyroidectomy in terms of specific survival or recurrence, in case of low risk of recurrence (T1-2N0). However, as a precaution, and taking into account current data, thyroidectomy is recommended in N0 thyroid papillary cancers with aggressive subtype, with even minimal infiltration of perithyroid tissue and/or vascular invasion, and in N1 cancers with more than 5 lymphadenopathies or lymphadenopathies with a major axis greater than or equal to 0.2 cm. Other forms of papillary cancer should be treated with lobectomy, as risk of morbidity is low and hospital stay is short. Lobectomy allows reliable monitoring, especially by ultrasound. On the other hand, total thyroidectomy, despite a higher rate of surgical complications due to the risk of recurrent paralysis and permanent hypoparathyroidism, is nevertheless preferable to lobectomy. Indeed lobectomy is not always avoiding hormone replacement therapy, for more precise monitoring by thyroglobulin assay, which is an uninterpretable tool after lobectomy but allows early diagnosis of local or metastatic recurrence with reducing mortality. Thus, in situations where the diagnostic criteria for high-risk cancer are not rigorously determined or taken into account, thyroidectomy is recommended. In addition, it will remain preferable as long as the recommendations for administration of radioactive iodine do not change in favor of use reserved for high-risk cancers as in US guidelines.



中文翻译:

争议:对于 > 1 cm 的分化型甲状腺癌,支持或反对甲状腺叶切除术?

在这篇有争议的文章中,讨论了肺叶切除术与甲状腺全切除术在分化型甲状腺癌中的各自优势。作者得出结论,在复发风险低(T1-2N0)的情况下,就特定生存或复发而言,肺叶切除术与甲状腺切除术具有相同的肿瘤学预后。然而,作为预防措施,并考虑到目前的数据,对于具有侵袭性亚型的 N0 甲状腺乳头状癌,即使甲状腺周围组织和/或血管侵犯最小,以及具有超过 5 个淋巴结病或淋巴结病的 N1 癌,建议进行甲状腺切除术。大于或等于 0.2 的主轴 厘米。其他形式的乳头状癌应采用肺叶切除术治疗,因为发病风险低且住院时间短。肺叶切除术可以进行可靠的监测,尤其是通过超声。另一方面,尽管由于复发性麻痹和永久性甲状旁腺功能减退的风险导致手术并发症发生率较高,但甲状腺全切除术仍优于肺叶切除术。事实上,肺叶切除术并不总是避免激素替代治疗,以便通过甲状腺球蛋白测定进行更精确的监测,甲状腺球蛋白测定是肺叶切除术后无法解释的工具,但可以早期诊断局部或转移性复发并降低死亡率。因此,在没有严格确定或考虑高危癌症诊断标准的情况下,建议进行甲状腺切除术。此外,

更新日期:2021-05-03
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