ABSTRACT

This study describes Green synthesis of two metal oxide nanoparticles MnO₂NPs and CuONPs using the oat biomass. The electrocatalytic activity of the synthesized metal oxide nanoparticles was investigated by fabricating two modified sensors enriched with MnO₂NPs and CuONPs as a coated layer on the surface of the sensors and utilized to quantify antibacterial drugs cephalexin (CPX) and cefazolin (CFZ) in their commercial products and biosamples. The tested drugs were incorporated with the precipitating agents phosphomolybdic acid and phosphotungstic acid to form CPX-PM and CFZ-PT as electroactive materials, respectively. Conductivity enhancement of the fabricated modified sensors CPX-PM-MnO₂NPs and CFZ-PT-CuONPs was determined and the outcomes compared to the results obtained from the conventional types of the same sensors. Linear relationships were recorded between the sensory potentials of the enriched metal oxide nanoparticles in the ranges of 1.0 × 10^-8-1.0 × 10^-2 and 1.0 × 10^-10-1.0 × 10^-2 mol L^-1 with lower limits of detection 5.6 × 10^-9 and 5.7 × 10^-11 mol L^-1 for CPX-PM-MnO₂NPs and CFZ-PT-CuONPs with respect to 1.0 × 10^-6-1.0 × 10^-2 mol L^-1 of their conventional coated wire types. The fabricated sensors provide excellent sensitivity and selectivity towards the determination of CPX and CFZ in its commercial and biosamples.

摘要

这项研究描述了使用燕麦生物质绿色合成两种金属氧化物纳米颗粒MnO ₂ NPs和CuONPs。通过在传感器表面上制备两个富含MnO ₂ NPs和CuONPs的修饰传感器作为涂层，研究了合成的金属氧化物纳米颗粒的电催化活性，并用于量化抗菌药物中的头孢氨苄（CPX）和头孢唑林（CFZ）商业产品和生物样品。将受试药物与沉淀剂磷钼酸和磷钨酸混合，分别形成CPX-PM和CFZ-PT作为电活性材料。改进的修饰传感器CPX-PM-MnO _2的电导率增强确定了NP和CFZ-PT-CuONP，并将结果与​​从相同类型的常规传感器获得的结果进行了比较。在检测限较低的情况下，在1.0×10 ^-8 -1.0×10 ^-2和1.0×10 ^-10 -1.0×10 ^-2 mol L ^-1范围内，记录了富金属氧化物纳米颗粒的感官电位之间的线性关系。CPX-PM-MnO ₂ NP和CFZ-PT-CuONP的5.6×10 ^-9和5.7×10 ^-11 mol L ^-1相对于1.0×10 ^-6 -1.0×10 ^-2 mol L ^-1的传统涂层电线类型。制成的传感器为商业和生物样品中CPX和CFZ的测定提供了出色的灵敏度和选择性。