当前位置: X-MOL 学术J. Interv. Cardiol. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
The 11-Year Prognostic Impact of Chronic Total Occlusion in the Noninfarct-Related Coronary Artery on Patients with Acute Myocardial Infarction
Journal of Interventional Cardiology ( IF 2.1 ) Pub Date : 2021-03-18 , DOI: 10.1155/2021/6646804
Xuanqi An 1 , Jingang Yang 1 , Kefei Dou 1 , Yuejin Yang 1
Affiliation  

Background. The prognostic significance of CTO in the non-IRA in patients with AMI has been under dispute. Relevant long-term follow-up studies are lacking. Hypothesis. CTO in the non-IRA is an independent predictor of poor long-term prognosis in patients with AMI. Methods. We prospectively enrolled 2336 patients with AMI who received emergent percutaneous coronary intervention successfully from January 2006 to May 2011. Our primary endpoints included death from cardiovascular causes, recurrent myocardial infarction, stroke, and target-vessel revascularization. We adopted Cox regression analysis adjusted for confounders to analyze the impact of CTO in the non-IRA on long-term mortalities. Results. We identified 628 (27.6%) subjects with CTO in the non-IRA among 2282 AMI patients. After a mean follow-up duration of 134.3 months, we found the CTO group had significantly higher MACCE rate than the group without CTO (30.4% versus 24.3%, ). CTO in the non-IRA independently predicted 11-year MACCE in the male AMI subgroup (hazard ratio 1.28, 95% confidence interval 1.06 to 1.54, ) and in the male NSTEMI subgroup (hazard ratio 1.53, 95% confidence interval 1.09 to 2.15, ). In the CTO group, three-vessel disease independently predicted 11 year MACCE (hazard ratio 2.05, 95% confidence interval 1.29 to 3.28, ). Conclusions. Our long-term observational study supported the association between CTO in the non-IRA and poorer prognosis in AMI patients undergoing primary PCI. We identified the group with the three-vessel disease as a high-risk subgroup in patients with CTO in the non-IRA.

中文翻译:

非梗死相关冠状动脉慢性完全闭塞对急性心肌梗死患者的 11 年预后影响

背景。CTO 在 AMI 患者非 IRA 中的预后意义一直存在争议。缺乏相关的长期随访研究。假设。非 IRA 中的 CTO 是 AMI 患者长期预后不良的独立预测因子。方法。我们前瞻性地招募了 2336 名 AMI 患者,这些患者在 2006 年 1 月至 2011 年 5 月期间成功接受了紧急经皮冠状动脉介入治疗。我们的主要终点包括心血管原因死亡、复发性心肌梗死、卒中和靶血管血运重建。我们采用针对混杂因素调整的 Cox 回归分析来分析非 IRA 中 CTO 对长期死亡率的影响。结果. 我们在 2282 名 AMI 患者中确定了 628 名(27.6%)非 IRA 的 CTO 受试者。平均随访 134.3 个月后,我们发现 CTO 组的 MACCE 发生率明显高于未 CTO 组(30.4% 对 24.3%,)。非 IRA 的 CTO 独立预测男性 AMI 亚组的 11 年 MACCE(风险比 1.28,95% 置信区间 1.06 至 1.54,和男性 NSTEMI 亚组(风险比 1.53,95% 置信区间 1.09 至 2.15,)。在 CTO 组中,三支血管疾病独立预测 11 年 MACCE(风险比 2.05,95% 置信区间 1.29 至 3.28,)。 结论。我们的长期观察性研究支持非 IRA 中的 CTO 与接受直接 PCI 的 AMI 患者预后较差之间的关联。我们将患有三支血管疾病的组确定为非 IRA 中 CTO 患者的高风险亚组。
更新日期:2021-03-18
down
wechat
bug