Abstract Purpose: To corroborate whether vessels on the surface of the optic nerve head can provide protection against the loss of underlying axons in subjects with manifest glaucoma. Methods: In this pilot study, thirty-six glaucomatous eyes with a perimetric defect in the Bjerrum area were included. The retinal nerve fiber layer (RNFL) thickness was measured in each of the sectors of the clock-hour map obtained by Cirrus HD-OCT considering the presence or absence of blood vessels. These sectors were related with their corresponding areas of the retina examined in the visual field using a mathematical model of the retina introduced by Jansonius, in order to determine the values of threshold sensitivity in those areas in the presence or absence of vessels. Results: We corroborated the protective role of the blood vessel for peripapillary RNFL thickness of clock-hour 12 despite obtaining a p-value (p = 0.023; w = 228.5) close to the acceptance zone (p ≥ 0.05). The mean plus-or-minus sign standard deviation with vessel and without vessel were 70.95 plus-or-minus sign 24.35 and 88.46 plus-or-minus sign 23.96, respectively. No differences were found between the mean values of threshold sensitivity to the presence or absence of blood vessels in each of the sectors considered. Conclusions: Our findings do not allow us to affirm that there is an association between the presence of a vessel and protection against glaucomatous damage in subjects with an advanced manifestation of the disease. In the future, more extensive studies are needed to study this relationship in subjects with early glaucoma. Key words: astrocytes, visual field, primary open-angle glaucoma, aqueous humor, blood vessel.

中文翻译：

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关于青光眼损害中血管的保护作用：横向研究。

摘要目的：证实视神经乳头表面的血管是否可为患有明显青光眼的受试者提供保护，以防止其潜在的轴突丢失。方法：在该初步研究中，包括了36例在Bjerrum地区具有视野缺损的青光眼眼。考虑到是否存在血管，在通过Cirrus HD-OCT获得的时钟图的每个扇区中测量视网膜神经纤维层（RNFL）的厚度。这些区域与它们在视野中使用Jansonius引入的视网膜数学模型在视网膜上检查的相应区域相关，以确定在有或没有血管的情况下这些区域的阈值敏感度值。结果：尽管获得了接近接受区（p≥0.05）的p值（p = 0.023； w = 228.5），但我们证实了血管对十二小时的视乳头周围RNFL厚度的保护作用。带血管和不带血管的平均正负号标准差分别为70.95正负号24.35和88.46正负号23.96。在所考虑的每个部门中，对是否存在血管的阈值敏感度的平均值之间均未发现差异。结论：我们的发现不能使我们确认在患有疾病的晚期患者中，血管的存在与对青光眼损害的保护之间存在关联。将来，需要更广泛的研究来研究早期青光眼患者的这种关系。关键字：