Diet-based prevention of malignant transformation contributes to the maintenance of quality of life by avoiding a battle against cancer. Invasion is one of the features of malignant breast cancer, and the prevention of invasion may reduce breast cancer malignancy. A recently established early breast cancer model system showed mammary ductal dysplasia with invasion in mice. This study utilized the model system and investigated the effect of fermented barley extract (FBE), a food material. The elastic fiber layer is the outermost layer of the mammary duct. A reduction in the elastic fiber layer was observed in the mammary glands of the model system, whereas supplementation with 8% FBE containing water prevented this reduction. Moreover, we found that FBE supplementation prevented mammary epithelial cell invasion. Based on our findings, FBE might be a candidate material for a diet-based prevention of early breast cancer invasion.

基于饮食的恶性转化预防通过避免与癌症的斗争而有助于维持生活质量。侵袭是恶性乳腺癌的特征之一，而预防侵袭可降低乳腺癌的恶性程度。最近建立的早期乳腺癌模型系统显示出乳腺导管发育不良并伴有小鼠侵袭。这项研究利用模型系统并研究了食品原料大麦提取物（FBE）的效果。弹性纤维层是乳腺导管的最外层。在模型系统的乳腺中观察到弹性纤维层减少，而补充8％的FBE则阻止了这种减少。此外，我们发现补充FBE可以防止乳腺上皮细胞浸润。根据我们的发现，