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Integrative Base Ontology for the Research Analysis of Alzheimer’s Disease-Related Mild Cognitive Impairment
Frontiers in Neuroinformatics ( IF 3.5 ) Pub Date : 2021-01-12 , DOI: 10.3389/fninf.2021.561691
Alba Gomez-Valades , Rafael Martinez-Tomas , Mariano Rincon

The early detection of mild cognitive impairment (MCI) has become a priority in Alzheimer’s disease (AD) research since it is a transition phase between normal aging and dementia. However, information regarding MCI and AD is scattered in disparate formats and standards generated by different technologies, which makes it difficult to work with them manually. Ontologies have emerged as a solution to this problem because of their capability of homogenization and consensus in the representation and reuse of data. In this context, an ontology that integrates the four main domains of neurodegenerative diseases, diagnostic tests, cognitive functions and brain areas will become significantly useful in research. Here, we introduce the first approach to this ontology, the Neurocognitive Integrated Ontology (NIO), which integrates the knowledge regarding neuropsychological tests, AD, cognitive functions, and brain areas. This ontology enables interoperability and facilitates access to data by integrating dispersed knowledge across different disciplines, rendering it useful for other research groups. To ensure the stability and reusability of NIO, the ontology was developed following the ontology-building life cycle, integrating and expanding terms from four different reference ontologies. The usefulness of this ontology was validated through use-case scenarios.

中文翻译:

综合基础本体论,用于阿尔茨海默氏病相关轻度认知障碍的研究分析

早发现轻度认知障碍(MCI)已成为阿尔茨海默病(AD)研究的重点,因为它是正常衰老和痴呆症之间的过渡阶段。但是,有关MCI和AD的信息散布在不同技术生成的不同格式和标准中,这使得手动处理它们变得困难。由于本体在数据表示和重用方面具有同质化和共识的能力,因此已成为解决该问题的一种方法。在这种情况下,将神经退行性疾病,诊断测试,认知功能和大脑区域的四个主要领域整合在一起的本体将在研究中变得非常有用。在这里,我们介绍这种本体的第一种方法,即神经认知集成本体(NIO),它整合了有关神经心理学测试,AD,认知功能和大脑区域的知识。通过整合不同学科中分散的知识,该本体可实现互操作性并促进对数据的访问,从而使其对其他研究小组有用。为了确保NIO的稳定性和可重用性,该本体是根据本体构建生命周期开发的,集成和扩展了来自四种不同参考本体的术语。通过用例场景验证了该本体的有用性。本体是根据本体构建生命周期开发的,集成和扩展了来自四种不同参考本体的术语。通过用例场景验证了该本体的有用性。本体是根据本体构建生命周期开发的,集成和扩展了来自四种不同参考本体的术语。该本体的有用性已通过用例场景进行了验证。
更新日期:2021-03-17
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