Indwelling urinary catheters (IUCs) are used in clinical settings to assist detrusor contraction in hospitalized patients. However, an inserted IUC often causes catheter‐related bladder discomfort. To resolve this, we propose an IUC coupled with local, sustained release of an anesthetic drug, lidocaine. For this, a thin strand composed of poly (lactic‐co‐glycolic acid) and lidocaine was separately prepared as a drug delivery carrier, which was then wound around the surface of the IUC to produce the drug‐delivery IUC. Our results revealed that the drug‐delivery IUC could exert the pain‐relief effects for up to 7 days when placed in the bladder of living rats. Cystometrogram tests indicated that the drug‐delivery IUC could significantly relieve bladder discomfort compared with the IUC without lidocaine. Furthermore, the expression of pain‐related inflammatory markers, such as nerve growth factor, cyclooxygenase‐2, and interleukin‐6 in the biopsied bladder tissues was significantly lower when the drug‐delivery IUC was used. Therefore, we conclude that an IUC simply assembled with a drug‐loaded polymer strand can continuously release lidocaine to allow for the relief of bladder discomfort during the period of IUC insertion.

中文翻译：

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留置导尿管与利多卡因负载的聚合物线组装在一起，可局部持续缓解膀胱不适

在临床环境中使用留置导尿管（IUC）来协助住院患者的逼尿肌收缩。但是，插入的IUC通常会导致与导管相关的膀胱不适。为了解决这个问题，我们提出了一种IUC，并与麻醉药利多卡因的局部持续释放相结合。为此，分别制备了由聚（乳酸-乙醇酸）和利多卡因组成的细链作为药物输送载体，然后将其缠绕在IUC的表面以产生药物输送IUC。我们的研究结果表明，将药物递送的IUC放置在活着的大鼠的膀胱中，最多可以起到7天的止痛作用。血压计测试表明，与不使用利多卡因的IUC相比，药物输送IUC可以显着缓解膀胱不适。此外，使用药物递送IUC时，与疼痛相关的炎性标志物（如神经生长因子，环氧合酶2和白细胞介素6）在膀胱活检组织中的表达显着降低。因此，我们得出的结论是，简单地将IUC与载有药物的聚合物链组装在一起，就可以连续释放利多卡因，从而在IUC插入期间减轻膀胱不适。