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Quantitative Electroencephalography Findings in Patients With Diabetes Mellitus
Clinical EEG and Neuroscience ( IF 2 ) Pub Date : 2021-03-17 , DOI: 10.1177/1550059421997657
Özden Öksüz 1 , Mehmet Güven Günver 2 , Mehmet Kemal Arıkan 3
Affiliation  

Objective. Diabetes mellitus (DM) causes structural central nervous system (CNS) impairment, and this situation can be detected by quantitative electroencephalography (QEEG) findings before cognitive impairment is clinically observed. The main aim of this study is to uncover the effect of DM on brain function. Since QEEG reflects the CNS functioning, particularly in cognitive aspects, we expected electrophysiological clues to be found for prevention and follow-up in DM-related cognitive decline. Since a majority of the psychiatric population have cognitive dysfunction, we have given particular attention to those people. It was stated that a decrease was observed in the posterior cortical alpha power due to the hippocampal atrophy by several previous studies and we hypothesize that decreased alpha power will be observed also in DM. Methods. This study included 2094 psychiatric patients, 207 of whom were diagnosed with DM and 1887 of whom were not diagnosed with DM, and QEEG recordings were performed. Eyes-closed electroencephalography data were segmented into consecutive 2 s epochs. Fourier analysis was performed by averaging across 2 s epochs without artifacts. The absolute alpha power in the occipital regions (O1 and O2) of patients with and without DM was compared. Results. In the DM group, a decrease in the absolute alpha, alpha 1, and alpha 2 power in O1 and O2 was observed in comparison with the control group. It was determined that the type of psychiatric diagnosis did not affect QEEG findings. Conclusion. The decrease in absolute alpha power observed in patients diagnosed with DM may be related to the CNS impairment in DM. QEEG findings in DM can be useful while monitoring the CNS impairment, diagnosing DM-related dementia, in the follow-up of the cognitive process, constructing the protocols for electrophysiological interventions like neurofeedback and transcranial magnetic stimulation and monitoring the response to treatment.



中文翻译:

糖尿病患者的定量脑电图检查结果

客观的. 糖尿病 (DM) 会导致结构性中枢神经系统 (CNS) 损伤,这种情况可以在临床观察到认知障碍之前通过定量脑电图 (QEEG) 发现来检测。本研究的主要目的是揭示 DM 对大脑功能的影响。由于 QEEG 反映了中枢神经系统的功能,特别是在认知方面,我们预计可以找到电生理学线索来预防和随访 DM 相关的认知衰退。由于大多数精神病患者有认知功能障碍,我们特别关注这些人。之前的几项研究表明,由于海马萎缩,观察到后皮质 α 功率降低,我们假设 DM 中也会观察到降低的 α 功率。方法。本研究纳入 2094 名精神病患者,其中 207 人被诊断为 DM,其中 1887 人未被诊断为 DM,并进行了 QEEG 记录。闭眼脑电图数据被分割成连续的 2 s 时期。傅里叶分析是通过在 2 s 时期内进行平均而没有伪影。比较了有和没有 DM 患者枕区(O1 和 O2)的绝对 α 功率。结果。在 DM 组中,与对照组相比,观察到 O1 和 O2 中的绝对 alpha、alpha 1 和 alpha 2 功率降低。确定精神病诊断的类型不影响 QEEG 的结果。结论. 在诊断为 DM 的患者中观察到的绝对 α 功率下降可能与 DM 中的 CNS 损伤有关。DM 中的 QEEG 发现可用于监测 CNS 损伤、诊断 DM 相关痴呆、跟踪认知过程、构建电生理干预方案(如神经反馈和经颅磁刺激)以及监测对治疗的反应。

更新日期:2021-03-17
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