Introduction. Polyethylene glycol-electrolyte lavage solution plus ascorbic acid (PEG-ELS-Asc) has been recommended for colonoscopy, but little is known about the safety of PEG-ELS-Asc in patients with chronic kidney disease (CKD). The aim of this study was to determine its safety and efficacy in CKD patients. Methods. Blood and urine samples prospectively collected before and after same-day bowel preparation for colonoscopy with the conventional volume of PEG-ELS-Asc, vital signs before and after colonoscopy, and adverse events within 30 days postcolonoscopy were analyzed in consenting patients with CKD. The cleansing level was evaluated with the Boston bowel preparation score (BBPS) from colonoscopic findings. Results. Of 57 patients enrolled, 1 was excluded for refusal. Serum bicarbonate significantly dropped, and blood hemoglobin, serum total protein, albumin, aspartate aminotransferase, alanine aminotransferase, lactate dehydrogenase, total bilirubin, and uric acid significantly rose after bowel preparation, although these changes were not clinically important. Only in nondialysis patients did the platelet count and potassium significantly rise, although these changes were not clinically important either. Renal function, such as the urea, creatinine, and estimated glomerular filtration rate, was not significantly altered. An adequate bowel cleansing score, , was achieved in 94% of patients. The blood pressure and heart rate were not significantly different between before and after colonoscopy in either nondialysis () or dialysis () patients. There were no adverse events associated with bowel preparation and colonoscopy within 30 days postcolonoscopy. Conclusions. The conventional volume of same-day bowel preparation with PEG-ELS-Asc may be safe and effective in CKD patients.

中文翻译：

---

聚乙二醇溶液加抗坏血酸用于慢性肾病患者结肠镜检查肠道准备的安全性

介绍。聚乙二醇电解质灌洗液加抗坏血酸 (PEG-ELS-Asc) 已被推荐用于结肠镜检查，但人们对 PEG-ELS-Asc 在慢性肾病 (CKD) 患者中的安全性知之甚少。本研究的目的是确定其在 CKD 患者中的安全性和有效性。方法。在同意的 CKD 患者中，对使用常规量的 PEG-ELS-Asc 进行结肠镜检查的当天肠道准备前后前瞻性收集的血液和尿液样本、结肠镜检查前后的生命体征以及结肠镜检查后 30 天内的不良事件进行分析。清洁水平通过结肠镜检查结果的波士顿肠道准备评分（BBPS）进行评估。结果。在 57 名患者中，有 1 名因拒绝而被排除。肠道准备后血清碳酸氢盐显着下降，血红蛋白、血清总蛋白、白蛋白、天门冬氨酸转氨酶、丙氨酸转氨酶、乳酸脱氢酶、总胆红素和尿酸显着升高，尽管这些变化在临床上并不重要。仅在非透析患者中​​，血小板计数和钾含量显着升高，尽管这些变化在临床上也不重要。肾功能，如尿素、肌酐和估计肾小球滤过率，没有显着改变。足够的肠道清洁分数，， 94% 的患者实现了这一目标。无论是非透析患者，结肠镜检查前后的血压和心率均无显着差异（）或透析（）患者。结肠镜检查后 30 天内没有发生与肠道准备和结肠镜检查相关的不良事件。结论。当天使用 PEG-ELS-Asc 进行常规肠道准备对于 CKD 患者可能是安全有效的。