After the clinical use of epalrestat that contains a rhodanine ring, in type II diabetes mellitus and diabetic complications, rhodanin-based compounds have become an important class of heterocyclic in the field of medicinal chemistry. Various modifications to the rhodanine ring have led to a broad spectrum of biological activity of these compounds. Synthesis of rhodanine derivatives, depended on advenced throughput scanning hits, frequently causes potent and selective modulators of targeted enzymes or receptors, which apply their pharmacological activities through different mechanisms of action. Rhodanine-based compounds will likely stay a privileged scaffold in drug discovery because of different probability of chemical modifications of the rhodanine ring. We have, therefore reviewed their biological activities and structure activity relationship.

在II型糖尿病和糖尿病并发症中，含有罗丹宁环的依帕司他临床应用后，基于罗丹宁的化合物已成为药物化学领域中重要的杂环类。罗丹宁环的各种修饰已导致这些化合物的广泛的生物活性。罗丹宁衍生物的合成，取决于先进的通量扫描命中率，通常会导致目标酶或受体的有效和选择性调节剂，其通过不同的作用机制发挥其药理活性。基于罗丹宁的化合物可能会在药物开发中保留优先权，因为罗丹宁环发生化学修饰的可能性不同。因此，我们已经审查了它们的生物活性与结构活性的关系。