ABSTRACT

Introduction

The importance of vaccine thermostability has been discussed in the literature. Nevertheless, the challenge of developing thermostable vaccine adjuvants has sometimes not received appropriate emphasis. Adjuvants comprise an expansive range of particulate and molecular compositions, requiring innovative thermostable formulation and process development approaches.

Areas covered

Reports on efforts to develop thermostable adjuvant-containing vaccines have increased in recent years, and substantial progress has been made in enhancing the stability of the major classes of adjuvants. This narrative review summarizes the current status of thermostable vaccine adjuvant development and looks forward to the next potential developments in the field.

Expert opinion

As adjuvant-containing vaccines become more widely used, the unique challenges associated with developing thermostable adjuvant formulations merit increased attention. In particular, more focused efforts are needed to translate promising proof-of-concept technologies and formulations into clinical products.

中文翻译：

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开发热稳定疫苗佐剂

摘要

介绍

疫苗热稳定性的重要性已在文献中进行了讨论。然而，开发热稳定疫苗佐剂的挑战有时没有得到适当的重视。佐剂包含范围广泛的颗粒和分子成分，需要创新的热稳定性配方和工艺开发方法。

涵盖的领域

近年来，有关开发含热稳定佐剂疫苗的报道有所增加，在提高主要佐剂类别的稳定性方面取得了实质性进展。这篇叙述性综述总结了热稳定疫苗佐剂开发的现状，并展望了该领域的下一个潜在发展。

专家意见

随着含佐剂疫苗的应用越来越广泛，与开发热稳定佐剂制剂相关的独特挑战值得更多关注。特别是，需要更加集中精力将有前景的概念验证技术和配方转化为临床产品。