Glaucoma is the leading cause of irreversible blindness around the world. With its slow asymptomatic progression, there is an emphasis on early detection and frequent monitoring. A novel microfluidic contact lens has been established as a potential way to track the fluctuations of the intraocular pressure (IOP) which is a key indicator for diagnosing and monitoring glaucoma progression. The purpose of this article is to determine the effect of physiological variations of the eye on the performance of the microfluidic contact lens. Ultrasound biomicroscopy (UBM) was used to measure the central corneal thickness (CCT) and radius of corneal curvature (RCC) for a series of 16 fresh enucleated porcine eyes. The effect of these corneal anatomic features on device performance was then assessed by systematically adjusting intraocular pressure from 10 to 34 mmHg and monitoring the device indicator response. The performance of the microfluidic contact lens was determined by finding the amount the indicator fluid shifted in position as a result of 1 mmHg IOP increase. The relationship between IOP and indicator fluid was found to be linear for all eyes. The slope of the indicator fluid movement as a result of the IOP was evaluated against the CCT and RCC of each porcine eye. This yielded low correlation coefficients, 0.057 for CCT and 0.024 for RCC, meaning that these physiological differences showed no systematic impact on the measurements made with the contact lens.

青光眼是全世界不可逆失明的主要原因。由于其无症状进展缓慢，因此强调早期发现和频繁监测。一种新型微流体隐形眼镜已被确立为跟踪眼内压 (IOP) 波动的潜在方法，眼压 (IOP) 是诊断和监测青光眼进展的关键指标。本文的目的是确定眼睛的生理变化对微流体隐形眼镜性能的影响。超声生物显微镜 (UBM) 用于测量一系列 16 只新鲜去核猪眼的中央角膜厚度 (CCT) 和角膜曲率半径 (RCC)。然后通过系统地将眼压从 10 调整到 34 mmHg 并监测设备指标响应来评估这些角膜解剖特征对设备性能的影响。微流体隐形眼镜的性能是通过找到指示剂流体位置移动的量来确定的，因为 1 mmHg IOP 增加。发现所有眼睛的 IOP 和指示液之间的关系都是线性的。根据每只猪眼的 CCT 和 RCC 评估作为 IOP 结果的指示剂流体运动的斜率。这产生了低相关系数，CCT 为 0.057，RCC 为 0.024，这意味着这些生理差异对隐形眼镜的测量没有系统影响。微流体隐形眼镜的性能是通过找到指示剂流体位置移动的量来确定的，因为 1 mmHg IOP 增加。发现所有眼睛的 IOP 和指示液之间的关系都是线性的。根据每只猪眼的 CCT 和 RCC 评估作为 IOP 结果的指示剂流体运动的斜率。这产生了低相关系数，CCT 为 0.057，RCC 为 0.024，这意味着这些生理差异对隐形眼镜的测量没有系统影响。微流体隐形眼镜的性能是通过找到指示剂流体位置移动的量来确定的，因为 1 mmHg IOP 增加。发现所有眼睛的 IOP 和指示液之间的关系都是线性的。相对于每只猪眼的 CCT 和 RCC 评估作为 IOP 结果的指示剂流体运动的斜率。这产生了低相关系数，CCT 为 0.057，RCC 为 0.024，这意味着这些生理差异对隐形眼镜的测量没有系统影响。根据每只猪眼的 CCT 和 RCC 评估作为 IOP 结果的指示剂流体运动的斜率。这产生了低相关系数，CCT 为 0.057，RCC 为 0.024，这意味着这些生理差异对隐形眼镜的测量没有系统影响。根据每只猪眼的 CCT 和 RCC 评估作为 IOP 结果的指示剂流体运动的斜率。这产生了低相关系数，CCT 为 0.057，RCC 为 0.024，这意味着这些生理差异对隐形眼镜的测量没有系统影响。