WD40 repeat (WDR) domain is one of the most abundant protein interaction domains in the human proteome. More than 360 protein interaction domains have been annotated until now. WDR domains frequently mediate interaction with peptide regions of important interaction partners during a variety of biological processes. Proteins with WDR domain which is typically a seven-bladed β propeller, are continuously being discovered. They represent a large class of proteins that are likely to be central proteins. WDR domain-containing protein 76 (WDR76) is a member of WDR domain-containing protein. It is still poorly understood with possible involvement in DNA damage repair, apoptosis, cell cycle progression, and gene expression regulation. With further study on WDR76, knowledge of its basic functions and its role in different pathophysiological processes are increasing. Diverse interactions between WDR76 and its partners are complex and made a study on WDR76 challenging. In the present review, we summarized the process of understanding WDR76, its physiological functions, the close relationship with human diseases, and further potential opportunity for target therapy.

中文翻译：

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WDR76 在多种相互作用和人类疾病中的作用。

WD40 重复 (WDR) 结构域是人类蛋白质组中最丰富的蛋白质相互作用结构域之一。到目前为止，已经注释了 360 多个蛋白质相互作用域。在各种生物过程中，WDR 结构域经常介导与重要相互作用伙伴的肽区域的相互作用。具有 WDR 结构域的蛋白质通常是一个七叶 β 螺旋桨，不断被发现。它们代表了一大类可能是中心蛋白质的蛋白质。WDR 结构域蛋白 76 (WDR76) 是 WDR 结构域蛋白的成员。它可能参与 DNA 损伤修复、细胞凋亡、细胞周期进程和基因表达调控，目前仍知之甚少。随着对 WDR76 的进一步研究，关于其基本功能及其在不同病理生理过程中作用的知识正在增加。WDR76 与其合作伙伴之间的多种相互作用是复杂的，这使得对 WDR76 的研究具有挑战性。在本综述中，我们总结了了解 WDR76 的过程、其生理功能、与人类疾病的密切关系以及进一步潜在的靶向治疗机会。