M. verticillata (Malvaceae) is a medicinal plant used in the treatment of wounds, boils, and liver injuries. The plant leaf extracts possess anti-inflammatory and antioxidant activities. Doxorubicin (DOX) is a potent chemotherapeutic agent used in the treatment of various cancers, but its clinical use is limited by acute and chronic cardiotoxicity. This study aims to evaluate the possible cardioprotective role of Malva verticillata against doxorubicin-induced cardiotoxicity. Thirty-six male albino rats were divided into six groups, (n = 6): G1: normal control (was given 1 ml/kg of NaCl, 0.9%, twice a week IP), G2: cardiotoxic group (was given 1 mg/kg of DOX twice a week IP). G3 and G4 were given 250 mg/kg and 500 mg/kg of M. verticillata, respectively, while G5 and G6: were given 250, 500 mg/kg of M. verticillata PO and 1 mg/kg IP of DOX. for 6 weeks. Total body weight was taken weekly and Heart: body weight ratio was calculated. Blood samples were collected for determination of serum lactate dehydrogenase (LDH), creatine phosphokinase (CPK) and Troponin, the hearts were removed and processed for histopathological examination. M. verticillata showed a significant dose-dependent reduction in the cardiac enzyme levels, LDH, CPK activities, and Troponin levels. The histopathological studies in rat hearts also supported those findings. The present study suggests that M. verticillata may have a novel and worthwhile cardioprotective effect against DOX-induced cardiotoxicity.

中文翻译：

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锦葵对阿霉素所致大鼠毒性的心脏保护作用。

verticillata（锦葵科）是一种用于治疗伤口，bo疮和肝损伤的药用植物。植物叶提取物具有抗炎和抗氧化活性。阿霉素（DOX）是用于治疗各种癌症的有效化学治疗剂，但其临床应用受到急性和慢性心脏毒性的限制。这项研究的目的是评估大叶锦葵对阿霉素诱导的心脏毒性的可能的心脏保护作用。将36只雄性白化病大鼠分为六组，（n = 6）：G1：正常对照组（给予1 ml / kg NaCl，0.9％，每周两次IP），G2：心脏毒性组（给予1 mg / kg DOX，每周两次IP）。分别向G3和G4分别施用250 mg / kg和500 mg / kg的褐斑葡萄球菌，而向G5和G6：分别提供250、500 mg / kg的褐斑葡萄球菌PO和1 mg / kg IP的DOX。持续6周。每周取总体重，并计算心脏：体重比。收集血样以确定血清乳酸脱氢酶（LDH），肌酸磷酸激酶（CPK）和肌钙蛋白，取出心脏并进行组织病理学检查。黄萎病菌显示出心脏酶水平，LDH，CPK活性和肌钙蛋白水平显着的剂量依赖性降低。大鼠心脏的组织病理学研究也支持了这些发现。本研究表明，网状分枝杆菌可能对DOX诱导的心脏毒性具有新颖而值得的心脏保护作用。取出心脏并进行组织病理学检查。黄萎病菌显示出心脏酶水平，LDH，CPK活性和肌钙蛋白水平显着的剂量依赖性降低。大鼠心脏的组织病理学研究也支持了这些发现。本研究表明，网状分枝杆菌可能对DOX诱导的心脏毒性具有新颖而值得的心脏保护作用。取出心脏并进行组织病理学检查。黄萎病菌显示出心脏酶水平，LDH，CPK活性和肌钙蛋白水平显着的剂量依赖性降低。大鼠心脏的组织病理学研究也支持了这些发现。本研究表明，网状分枝杆菌可能对DOX诱导的心脏毒性具有新颖而值得的心脏保护作用。