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Thalamic dysconnectivity in the psychosis risk syndrome and early illness schizophrenia
Psychological Medicine ( IF 6.9 ) Pub Date : 2021-03-15 , DOI: 10.1017/s0033291720004882
Susanna L Fryer 1, 2 , Jamie M Ferri 2 , Brian J Roach 2 , Rachel L Loewy 1 , Barbara K Stuart 1 , Alan Anticevic 3, 4 , Judith M Ford 1, 2 , Daniel H Mathalon 1, 2
Affiliation  

Background

Schizophrenia (SZ) is associated with thalamic dysconnectivity. Compared to healthy controls (HCs), individuals with SZ have hyperconnectivity with sensory regions, and hypoconnectivity with cerebellar, thalamic, and prefrontal regions. Despite replication of this pattern in chronically ill individuals, less is known about when these abnormalities emerge in the illness course and if they are present prior to illness onset.

Methods

Resting-state functional magnetic resonance imaging data were collected from psychosis risk syndrome (PRS) youth (n = 45), early illness SZ (ESZ) (n = 74) patients, and HCs (n = 85). Age-adjusted functional connectivity, seeded from the thalamus, was compared among the groups.

Results

Significant effects of group were observed in left and right middle temporal regions, left and right superior temporal regions, left cerebellum, and bilateral thalamus. Compared to HCs, ESZ demonstrated hyperconnectivity to all temporal lobe regions and reduced connectivity with cerebellar, anterior cingulate, and thalamic regions. Compared to HCs, PRS demonstrated hyperconnectivity with the left and right middle temporal regions, and hypoconnectivity with the cerebellar and other thalamic regions. Compared to PRS participants, ESZ participants were hyperconnected to temporal regions, but did not differ from PRS in hypoconnectivity with cerebellar and thalamic regions. Thalamic dysconnectivity was unrelated to positive symptom severity in ESZ or PRS groups.

Conclusions

PRS individuals demonstrated an intermediate level of thalamic dysconnectivity, whereas ESZ showed a pattern consistent with prior observations in chronic samples. These cross-sectional findings suggest that thalamic dysconnectivity may occur prior to illness onset and become more pronounced in early illness stages.



中文翻译:

精神病风险综合征和早期疾病精神分裂症中的丘脑连接失调

背景

精神分裂症 (SZ) 与丘脑连接障碍有关。与健康对照 (HCs) 相比,患有 SZ 的个体与感觉区域具有超连接性,而与小脑、丘脑和前额叶区域具有低连接性。尽管这种模式在慢性病患者中重复出现,但对于这些异常在病程中何时出现以及它们是否在疾病发作之前就存在,知之甚少。

方法

从精神病风险综合征 (PRS) 青年 ( n = 45)、早期疾病 SZ (ESZ) ( n = 74) 患者和 HCs ( n = 85)中收集静息状态功能磁共振成像数据。在各组之间比较了从丘脑播种的年龄调整后的功能连接性。

结果

在左右中颞区、左右上颞区、左侧小脑和双侧丘脑观察到组的显着效果。与 HCs 相比,ESZ 表现出与所有颞叶区域的超连接性,并降低了与小脑、前扣带回和丘脑区域的连接性。与 HC 相比,PRS 表现出与左右颞中区的超连接性,与小脑和其他丘脑区域的连接性降低。与 PRS 参与者相比,ESZ 参与者与颞区高度连接,但在与小脑和丘脑区域的低连接性方面与 PRS 没有区别。丘脑连接障碍与 ESZ 或 PRS 组的阳性症状严重程度无关。

结论

PRS 个体表现出中等水平的丘脑连接障碍,而 ESZ 表现出与先前在慢性样本中观察到的模式一致。这些横断面研究结果表明,丘脑连接失调可能发生在疾病发作之前,并在疾病早期阶段变得更加明显。

更新日期:2021-03-15
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