ABSTRACT

Introduction

Oral absorption of BCS IV drug benefits little from improved dissolution. Therefore, the absorption of BCS IV drug nanocrystals ‘as a whole’ strategy is preferred, and structural modification of nanocrystals is required. Surface modification helps the nanocrystals maintain particle structure before drug dissolution is needed, thus enhancing the oral absorption of BCS IV drugs and promoting therapeutic effect. Here, the main challenges and solutions of oral BCS IV drug nanocrystals delivery are discussed. Moreover, strategies for nanocrystal surface modification that facilitates oral bioavailability of BCS IV drugs are highlighted, and provide insights for the innovation in oral drug delivery.

Areas covered

Promising size, shape, and surface modification of nanocrystals have gained interests for application in oral BCS IV drugs.

Expert opinion

Nanocrystal surface modification is a feasible method to maintain the structural integrity of nanocrystals, and the introduced materials can also be modified to integrate additional functions to further facilitate the absorption of nanocrystals. It is expected that the absorption ‘as a whole’ strategy of nanocrystals will provide different choices for the oral BCS IV drugs.

中文翻译：

---

BCS IV 药物纳米晶体口服给药的当前策略：挑战、解决方案和未来趋势

摘要

介绍

BCS IV 药物的口服吸收从改善的溶出度中获益甚微。因此，首选 BCS IV 药物纳米晶体的“整体”吸收策略，并且需要对纳米晶体进行结构修饰。表面修饰有助于纳米晶体在需要药物溶解之前保持颗粒结构，从而增强 BCS IV 药物的口服吸收并促进治疗效果。在这里，讨论了口服 BCS IV 药物纳米晶体递送的主要挑战和解决方案。此外，突出了促进 BCS IV 药物口服生物利用度的纳米晶体表面修饰策略，并为口服药物递送的创新提供了见解。

覆盖区域

纳米晶体的有希望的尺寸、形状和表面改性在口服 BCS IV 药物中的应用引起了人们的兴趣。

专家意见

纳米晶表面修饰是保持纳米晶结构完整性的可行方法，引入的材料也可以通过修饰来整合额外的功能，以进一步促进纳米晶的吸收。预计纳米晶体的“整体吸收”策略将为口服 BCS IV 药物提供不同的选择。