Spectroscopy Letters ( IF 1.7 ) Pub Date : 2021-03-15 , DOI: 10.1080/00387010.2021.1893191 Ikechukwu P. Ejidike 1, 2 , Mercy O. Bamigboye 3 , Hadley S. Clayton 1
Abstract
The reaction of copper salts with Schiff base ligand: [4-[(1E)-N-{2-[(Z)-(4-methoxybenzylidene)amino]ethyl}ethanimidoyl]benzene-1,3-diol] derived from the condensation of ethylenediamine, 2-hydroxy-1-(4-hydroxyphenyl)ethenone and 4-methoxybenzaldehyde afforded copper complexes bearing chloride, bromide, thiocyanate, nitrate, and acetate. The complexes exhibited crystalline features and excellent thermal stability up to 450 °C. The powder X-ray diffraction pattern suggests a well-defined crystalline structure with average crystallite sizes of < 52 nm. The scavenging ability of 2,2-diphenyl-1-picrylhydrazyl and 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid radicals by the synthesized compounds was studied for their antioxidant potential and screening for antimicrobial activity by p-iodonitrotetrazolium chloride colorimetric assay. The investigated assays suggest that the synthesized compounds are potent antiradical and antimicrobial agents.
- Research highlights
An eco-friendly method was followed for the synthesis of functionalized tridentate ONN Schiff base ligand.
Five Schiff base copper(II) complexes were synthesized bearing chloride, bromide, thiocyanate, nitrate, and acetate.
Structural features were characterized by CHN, PXRD, TG-DTG, NMR, UV–Vis, and FT-IR spectro-analytical techniques.
Schiff base ligand and its copper complexes showed good to excellent DPPH and ABTS radicals scavenging capability.
Cu(II) complexes of Schiff base ligand (MEB) showed good antimicrobial properties via the p-iodonitrotetrazolium chloride (INT) colorimetric assay.
中文翻译:
含三齿Schiff碱的铜配合物的光谱,体外抗自由基和抗菌性评估,该Schiff碱来源于二羟基苯官能团和二氨基乙烯桥
摘要
铜盐与席夫碱配体的反应:[4-[((1 E)-N- {2-[(Z由乙二胺,2-羟基-1-(4-羟基苯基)乙酮和4-甲氧基苯甲醛缩合得到的)-(4-甲氧基亚苄基)氨基]乙基}亚氨基酰亚胺基]苯-1,3-二醇]制得带有氯化物的铜配合物,溴化物,硫氰酸盐,硝酸盐和乙酸盐。该配合物表现出结晶特征,并在高达450°C的温度下具有出色的热稳定性。粉末X射线衍射图表明具有明确定义的晶体结构,平均晶粒尺寸小于52nm。研究了合成化合物清除2,2-二苯基-1-吡啶并肼基和2,2'-叠氮基双(3-乙基苯并噻唑啉-6-磺酸基)的抗氧化能力,并通过p筛选其抗菌活性。-碘硝基四唑氯化物比色法。研究的测定表明合成的化合物是有效的抗自由基和抗微生物剂。
- 研究重点
遵循生态友好的方法合成功能化的三齿ONN Schiff碱配体。
合成了五种带有氯化物,溴化物,硫氰酸盐,硝酸盐和乙酸盐的席夫碱铜(II)配合物。
通过CHN,PXRD,TG-DTG,NMR,UV-Vis和FT-IR光谱分析技术对结构特征进行了表征。
席夫碱配体及其铜络合物表现出良好的DPPH和ABTS自由基清除能力。
Schiff碱配体(MEB)的Cu(II)配合物通过对碘碘代四唑氯化物(INT)比色法显示出良好的抗菌性能。