Microbial lipids are promising substitutes for petroleum and plant oil. However, the industrialization of microbial lipids is still limited and cannot compete with petrochemical petroleum due to its high production cost. Microorganisms capable of accumulating lipids and additional valuable chemicals are attractive for improving the economics of the microbial lipid production process. Compared with the increase in production of complex metabolic engineering to improve the overall economy, the multi‐chemical co‐production system is more advantageous in balancing the metabolic flux and optimal cell physiological recovery. In this review, various chemicals co‐produced with microbial lipids are classified according to their cell location. Efficient strategies, including the fermentation process and genetic engineering for regulating and enhancing such co‐production systems, are comprehensively discussed. The prospective and challenges during the scale‐up of lipids and valuable chemicals co‐production process are also highlighted. © 2021 Society of Chemical Industry and John Wiley & Sons, Ltd

中文翻译：

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与有价值的化学物质共同生产微生物脂质

微生物脂质是石油和植物油的有希望的替代品。然而，由于其高生产成本，微生物脂质的工业化仍然受到限制并且不能与石化石油竞争。能够积聚脂质和其他有价值的化学物质的微生物对于提高微生物脂质生产工艺的经济性具有吸引力。与增加复杂代谢工程的生产以改善整体经济状况相比，多化学联产系统在平衡代谢通量和最佳细胞生理恢复方面更具优势。在这篇综述中，与微生物脂质共同产生的各种化学物质根据它们在细胞中的位置进行分类。高效策略 包括发酵过程和用于调节和增强此类联产系统的基因工程，得到了全面的讨论。还着重指出了脂质和有价值的化学品联合生产过程扩大规模时的前景和挑战。©2021化学工业协会和John Wiley＆Sons，Ltd