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Maternal exposure to tributyltin during early gestation increases adverse pregnancy outcomes by impairing placental development
Environmental Toxicology ( IF 4.5 ) Pub Date : 2021-03-15 , DOI: 10.1002/tox.23127
Hui Liu 1 , Wenyu Jiang 1, 2 , Yafen Ye 1 , Bei Yang 1 , Xin Shen 1 , Siying Lu 1 , Jun Zhu 1 , Mengling Liu 1 , Chuanzhen Yang 1 , Haibin Kuang 1, 3
Affiliation  

Tributyltin (TBT) is a persistent organotin pollutant widely used as agricultural and wood biocides, exhibiting well-documented toxicity to reproductive functions in aquatic organisms. However, the effect of TBT on early pregnancy and placental development has been rarely studied in mice. Pregnant mice were fed with 0, 0.2, and 2 mg/kg/day TBT from gravid day 1 to day 8 or 13. TBT exposure led to an increase in the number of resorbed embryo and a reduction in the weight of fetus at gestational days 13. Further study showed that TBT significantly decreased placental weight and area, lowered laminin immunoreactivity and the expressions of placental development-related molecules including Fra1, Eomes, Hand1, and Ascl2. Moreover, TBT treatment markedly inhibited the placental proliferation and induced up-regulation of p53 and cleaved caspase-3 proteins, and down-regulation of Bcl-2 protein. In addition, TBT administration increased levels of malondialdehyde and H2O2 and decreased activities of catalase and superoxide dismutase. Collectively, these results suggested TBT-induced adverse pregnancy outcomes during early pregnancy might be involved in developmental disorders of the placenta via dysregulation of key molecules, proliferation, apoptosis, and oxidative stress.

中文翻译:

母亲在妊娠早期接触三丁基锡会损害胎盘发育,从而增加不良妊娠结局

三丁基锡 (TBT) 是一种持久性有机锡污染物,广泛用作农业和木材杀菌剂,对水生生物的生殖功能表现出有据可查的毒性。然而,很少在小鼠中研究 TBT 对早孕和胎盘发育的影响。从怀孕第 1 天到第 8 天或第 13 天,用 0、0.2 和 2 毫克/公斤/天的 TBT 给怀孕的小鼠喂食。 TBT 暴露导致再吸收胚胎数量的增加和妊娠天胎儿体重的减少13.进一步研究表明,TBT显著减少的胎盘重量和面积,降低了层粘连蛋白的免疫反应性和胎盘发育相关的分子,包括的表达FRA1EOMESHAND1,和ASCL2. 此外,TBT 处理显着抑制胎盘增殖并诱导 p53 和裂解的 caspase-3 蛋白的上调,以及 Bcl-2 蛋白的下调。此外,TBT 给药增加了丙二醛和 H 2 O 2 的水平并降低了过氧化氢酶和超氧化物歧化酶的活性。总的来说,这些结果表明 TBT 诱导的妊娠早期不良妊娠结局可能通过关键分子的失调、增殖、细胞凋亡和氧化应激参与胎盘发育障碍。
更新日期:2021-03-15
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