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Mapping CRISPR-Cas9 public and commercial innovation using The Lens institutional toolkit
Transgenic Research ( IF 3 ) Pub Date : 2021-03-15 , DOI: 10.1007/s11248-021-00237-y
Osmat Azzam Jefferson 1, 2 , Simon Lang 1 , Kenny Williams 1 , Deniz Koellhofer 1 , Aaron Ballagh 1 , Ben Warren 1 , Bernard Schellberg 1 , Roshan Sharma 1 , Richard Jefferson 1
Affiliation  

CRISPR-Cas9 is a revolutionary technology because it is precise, fast and easy to implement, cheap and components are readily accessible. This versatility means that the technology can deliver a timely end product and can be used by many stakeholders. In plant cells, the technology can be applied to knockout genes by using CRISPR–Cas nucleases that can alter coding gene regions or regulatory elements, alter precisely a genome by base editing to delete or regulate gene expression, edit precisely a genome by homology-directed repair mechanism (cellular DNA), or regulate transcriptional machinery by using dead Cas proteins to recruit regulators to the promoter region of a gene. All these applications can be for: 1) Research use (Non commercial), 2) Uses related product components for the technology itself (reagents, equipment, toolkits, vectors etc), and 3) Uses related to the development and sale of derived end products based on this technology. In this contribution, we present a prototype report that can engage the community in open, inclusive and collaborative innovation mapping. Using the open data at the Lens.org platform and other relevant sources, we tracked, analyzed, organized, and assembled contextual and bridged patent and scholarly knowledge about CRISPR-Cas9 and with the assistance of a new Lens institutional capability, The Lens Report Builder, currently in beta release, mapped the public and commercial innovation pathways of the technology. When scaled, this capability will also enable coordinated editing and curation by credentialed experts to inform policy makers, businesses and private or public investment.



中文翻译:

使用 The Lens 机构工具包映射 CRISPR-Cas9 公共和商业创新

CRISPR-Cas9 是一项革命性的技术,因为它精确、快速且易于实施,价格低廉且组件易于获取。这种多功能性意味着该技术可以及时交付最终产品,并可供许多利益相关者使用。在植物细胞中,该技术可以通过使用 CRISPR-Cas 核酸酶来敲除基因,该核酸酶可以改变编码基因区域或调控元件,通过碱基编辑精确改变基因组以删除或调节基因表达,通过同源定向精确编辑基因组修复机制(细胞 DNA),或通过使用死亡的 Cas 蛋白将调节因子募集到基因的启动子区域来调节转录机制。所有这些应用都可以用于:1) 研究用途(非商业),2)将相关产品组件用于技术本身(试剂、设备、工具包、载体等),3) 与基于该技术的衍生终端产品的开发和销售相关的用途。在此贡献中,我们提供了一份原型报告,可以让社区参与开放、包容和协作的创新映射。我们使用 Lens.org 平台和其他相关来源的开放数据,在新的 Lens 机构能力 The Lens Report Builder 的帮助下,跟踪、分析、组织和组合了有关 CRISPR-Cas9 的上下文和桥接专利和学术知识,目前处于测试版中,绘制了该技术的公共和商业创新途径。扩展后,此功能还将支持由有资质的专家进行协调编辑和策划,以通知政策制定者、企业以及私人或公共投资。

更新日期:2021-03-15
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