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Ruthenium-catalyzed hydrogenation of aromatic ketones using chiral diamine and monodentate achiral phosphine ligands
Catalysis Communications ( IF 3.7 ) Pub Date : 2021-03-13 , DOI: 10.1016/j.catcom.2021.106303
Mengna Wang , Ling Zhang , Hao Sun , Qian Chen , Jian Jiang , Linlin Li , Lin Zhang , Li Li , Chun Li

The Ru-catalyzed asymmetric hydrogenation of ketones with chiral diamine and monodentate achiral phosphine has been developed. A wide range of ketones were hydrogenated to afford the corresponding chiral secondary alcohols in good to excellent enantioselectivities (up to 98.1% ee). In addition, an appropriate mechanism for the asymmetric hydrogenation was proposed and verified by NMR spectroscopy.



中文翻译:

手性二胺和单齿非手性膦配体的钌催化加氢芳族酮

已经开发了Ru手性二胺和单齿非手性膦对Ru催化的酮的不对称加氢反应。将多种酮氢化,得到相应的手性仲醇,对映体选择性好至极好(高达98.1%ee)。此外,提出了合适的不对称氢化机理,并通过NMR光谱进行了验证。

更新日期:2021-03-22
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