Due to the variable clinical features and its rarity diagnosis of Cushing’s disease (CD) is often delayed. Clearly, awareness for CD needs to be raised, accompanied by the availability of simple and accurate screening tests. Late-night salivary cortisol (LNSC), 1mg dexamethasone suppression test (DST), and urinary free cortisol (UFC) have all been extensively studied, demonstrating high sensitivity and specificity for the diagnosis of Cushing’s syndrome. However, each of those well-established tests has its own distinctive features, making it preferable in specific clinical conditions and patient groups. To choose the most appropriate test in individual patients, an expert endocrinologist should be consulted. This review will discuss the pitfalls for each of those tests.

由于临床特征的变化及其对库欣病（CD）的罕见诊断，通常会延迟进行。显然，需要提高对CD的认识，并提供简单，准确的筛查测试。深夜唾液皮质醇（LNSC），1mg地塞米松抑制试验（DST）和尿液游离皮质醇（UFC）均已被广泛研究，证明其对库欣综合征的诊断具有很高的敏感性和特异性。但是，每项完善的测试均具有其独特的功能，因此在特定的临床条件和患者群体中更可取。要为个别患者选择最合适的检测方法，应咨询专家内分泌科医生。这篇评论将讨论每种测试的陷阱。