Cytostatics are compounds used in chemotherapy, known to be genotoxic, mutagenic, and teratogenic at low concentrations. The amount of cytostatic drugs prescribed increases every year as does their release into the aquatic ecosystems, which possibly is a major concern for the health of aquatic organisms. This study aimed to evaluate the putative toxicity of five cytostatics to fathead minnow (Pimephales promelas) larvae: tamoxifen, capecitabine, methotrexate, cyclophosphamide, and ifosfamide. Eggs collected post-fertilization were exposed for 6 days to a range of concentrations, including one above environmental level. At all environmental concentrations, no significant difference in mortality, hatching time, length, heart rate, and presence of malformations were found. Altogether, these cytostatics do not seem embryotoxic to fish. Although, an increased proportion of complete swim bladder were found after ifosfamide’s exposure, suggesting an interaction with the thyroid axis, involved in swim bladder development. Complementary work should address other endpoints, such as behavioral changes, reproductive success, and transgenerational effects.

细胞抑制剂是化学疗法中使用的化合物，已知在低浓度时具有遗传毒性，致突变性和致畸性。所规定的抑制细胞生长的药物的数量每年都随着其释放到水生生态系统中的增加而增加，这可能是对水生生物健康的主要关注。这项研究旨在评估五种细胞抑制剂对黑头呆min（Pimephales promelas）的假定毒性。）幼虫：他莫昔芬，卡培他滨，甲氨蝶呤，环磷酰胺和异环磷酰胺。受精后收集的卵在一系列浓度（包括高于环境水平的浓度）下暴露6天。在所有环境浓度下，死亡率，孵化时间，长度，心率和畸形均无显着差异。总之，这些细胞抑制剂对鱼类似乎没有胚胎毒性。虽然，异环磷酰胺暴露后发现完整的游泳膀胱比例增加，这暗示了与甲状腺轴的相互作用，参与了游泳膀胱的发育。补充工作应解决其他问题，例如行为改变，生殖成功和世代相传的影响。