Recent years have witnessed rise in the production of microbial fermentation of metabolites and proteins for industrial applications. The innovative method aims to improve the conventional batch fermentation and the separation. Furthermore, the idea of downstream processing of the target product enhances the efficiency of the overall process and makes it cost-effective and eco-friendly. Even though being cost-effective and eco-friendly, the process faces challenges in commercial applications. When the concentration of the final product/by-product reaches a certain level, feedback inhibition is a common problem encountered in the fermentation process. Excessive accumulation of end products/by-products in culture also inhibits cell growth and secretion of target metabolites. The fermentation results in the production of antibiotics, fungal metabolites, and amino acids, which come with serious inhibition problems. Hence, to mitigate such problems and enhance fermentation performance, extractive fermentation via in situ ion exchange adsorptive technique can be incorporated. The present review highlights the advances and suggests the strategies to resolve the inhibition problems using extractive fermentation via internal, external, and dispersed resin systems. Furthermore, methods for synthesis of resins are discussed and adsorption mechanism of ion exchanges is also elaborated.

近年来，已经见证了用于工业应用的代谢产物和蛋白质的微生物发酵生产的增加。该创新方法旨在改进常规的分批发酵和分离。此外，对目标产品进行下游加工的想法提高了整个过程的效率，并使其具有成本效益和生态友好性。尽管具有成本效益和环境友好性，但该工艺仍面临商业应用方面的挑战。当最终产物/副产物的浓度达到一定水平时，反馈抑制是发酵过程中遇到的常见问题。终产物/副产物在培养物中的过量积聚也抑制细胞生长和靶代谢物的分泌。发酵导致产生抗生素，真菌代谢产物和氨基酸，具有严重的抑制问题。因此，为了减轻这种问题并提高发酵性能，可以结合通过原位离子交换吸附技术的提取发酵。本综述着重介绍了这些进展，并提出了通过内部，外部和分散的树脂系统通过萃取发酵解决抑制问题的策略。此外，讨论了合成树脂的方法，并阐述了离子交换的吸附机理。本综述重点介绍了这些进展，并提出了通过内部，外部和分散的树脂系统利用萃取发酵解决抑制问题的策略。此外，讨论了合成树脂的方法，并阐述了离子交换的吸附机理。本综述着重介绍了这些进展，并提出了通过内部，外部和分散的树脂系统通过萃取发酵解决抑制问题的策略。此外，讨论了合成树脂的方法，并阐述了离子交换的吸附机理。