An association among adults between adverse childhood experiences (ACEs) and arterial stiffness and between arterial stiffness and cardiovascular disease has been established. Recent cross-sectional evidence suggests that ACEs is linked to the development and progression of arterial stiffness, but it remains unclear when these changes begin to manifest. We examine the relationship between ACEs and changes in arterial stiffness from childhood into adulthood using population-based longitudinal data. The Niagara Longitudinal Heart Study (NLHS) pilot data included 76 young adults (females = 44), with an average age of 21 years ( SD = 1), and had a follow-up period of 9 years. Mixed effects modeling was used to examine the effect of ACEs on changes in arterial stiffness over time adjusting for sex, changes in heart rate, systolic blood pressure, body mass index, and physical activity. Individuals with four or more ACEs have a greater increase in arterial stiffness over time from childhood into young adulthood. This increase was similar for both males and females and independent of the effects of change in heart rate, systolic blood pressure, body mass index, and physical activity. Exposure to ACEs is associated with greater increase in arterial stiffness, a marker for cardiovascular disease among adults. This suggests that interventions targeted at individuals with high exposure to ACEs early on in life could lower the risk of arterial stiffness and in turn the cascade of events leading to cardiovascular disease.

中文翻译：

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童年不良经历 (ACE) 预测从童年到成年早期动脉僵硬度增加：尼亚加拉纵向心脏研究的初步分析

成年人的不良童年经历 (ACE) 与动脉僵硬之间以及动脉僵硬与心血管疾病之间存在关联。最近的横断面证据表明 ACE 与动脉僵硬度的发展和进展有关，但尚不清楚这些变化何时开始显现。我们使用基于人群的纵向数据检查 ACE 与从儿童到成年的动脉僵硬度变化之间的关系。Niagara 纵向心脏研究 (NLHS) 试点数据包括 76 名年轻成人（女性 = 44），平均年龄为 21 岁（SD = 1），随访期为 9 年。混合效应模型用于检查 ACE 对动脉僵硬度随时间变化的影响，调整性别、心率、收缩压、体重指数和体力活动。具有四个或更多 ACE 的个体从童年到青年时期随着时间的推移，动脉僵硬度增加得更多。这种增加对于男性和女性来说是相似的，并且不受心率、收缩压、体重指数和身体活动变化的影响。暴露于 ACE 与动脉僵硬度的更大增加有关，动脉僵硬度是成人心血管疾病的标志。这表明，针对生命早期高暴露于 ACE 的个体的干预措施可以降低动脉僵硬的风险，进而降低导致心血管疾病的事件级联。这种增加对于男性和女性来说是相似的，并且不受心率、收缩压、体重指数和身体活动变化的影响。暴露于 ACE 与动脉僵硬度的更大增加有关，动脉僵硬度是成人心血管疾病的标志。这表明，针对生命早期高暴露于 ACE 的个体的干预措施可以降低动脉僵硬的风险，进而降低导致心血管疾病的事件级联。这种增加对于男性和女性来说是相似的，并且不受心率、收缩压、体重指数和身体活动变化的影响。暴露于 ACE 与动脉僵硬度的更大增加有关，动脉僵硬度是成人心血管疾病的标志。这表明，针对生命早期高暴露于 ACE 的个体的干预措施可以降低动脉僵硬的风险，进而降低导致心血管疾病的事件级联。