Several antitubercular medications are known to cause neuropsychiatric adverse reactions (ADR), including delirium, depression, mania, psychosis, and seizure disorder.^1–4 Neuropsychiatric ADR usually appears during the initiation of treatment or while changing from a previously prescribed regimen. The development of psychiatric ADR is rare during the continuation phase (CP), especially after a patient has been on a stable treatment regimen for several months.^4–6 We herein report a case of antitubercular treatment (ATT) induced acute psychosis in a young female after 21 months of regular supervised treatment for extrapulmonary multidrug-resistant tuberculosis (MDR-TB).

中文翻译：

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抗结核治疗引起的精神病晚期发生——一例报告

已知多种抗结核药物会引起神经精神不良反应 (ADR)，包括谵妄、抑郁、躁狂、精神病和癫痫发作。^1-4神经精神 ADR 通常出现在治疗开始期间或改变先前规定的治疗方案时。在持续阶段 (CP)，特别是在患者接受稳定治疗方案几个月后，很少会出现精神科 ADR。^4-6我们在此报告一例年轻女性在接受肺外耐多药结核病 (MDR-TB) 常规监督治疗 21 个月后，因抗结核治疗 (ATT) 诱发急性精神病。