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Inpatient Diuretic Management of Acute Heart Failure: A Practical Review
American Journal of Cardiovascular Drugs ( IF 3 ) Pub Date : 2021-03-12 , DOI: 10.1007/s40256-020-00463-5
Saif Ali 1 , Sharon Jung 1 , Shuktika Nandkeolyar 1 , Liset Stoletniy 1 , Antoine Sakr 1 , Frederik H Verbrugge 2, 3 , Anthony Hilliard 1 , Dmitry Abramov 1
Affiliation  

The inpatient treatment of acute heart failure (AHF) is aimed at achieving euvolemia, relieving symptoms, and reducing rehospitalization. Adequate treatment of AHF is rooted in understanding the pharmacokinetics and pharmacodynamics of select diuretic agents used to achieve decongestion. While loop diuretics remain the primary treatment of AHF, the dosing strategies of loop diuretics and the use of adjunct diuretic classes to augment clinical response can be complex. This review examines the latest strategies for diuretic management in patients with AHF, including dosing and monitoring strategies, interaction of diuretics with other medication classes, use adjunctive therapies, and assessing endpoints for diuretic. The goal of the review is to guide the reader through commonly encountered clinical scenarios and pitfalls in the diuretic management of patients with AHF.



中文翻译:

急性心力衰竭的住院利尿剂管理:实践回顾

急性心力衰竭(AHF)的住院治疗旨在实现血容量正常、缓解症状和减少再住院。AHF 的充分治疗植根于了解用于缓解充血的特定利尿剂的药代动力学和药效学。虽然袢利尿剂仍然是 AHF 的主要治疗方法,但袢利尿剂的给药策略和使用辅助利尿剂来增强临床反应可能很复杂。本综述审查了 AHF 患者利尿剂管理的最新策略,包括剂量和监测策略、利尿剂与其他药物类别的相互作用、使用辅助治疗以及评估利尿剂的终点。

更新日期:2021-03-12
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