Methadone maintenance treatment (MMT) is a common drug treatment for opioid dependence disorder. This treatment, with positive results, has many physical and psychological complications. The purpose of this study was to evaluate the effectiveness of dialectical behavioral therapy (DBT) on emotional regulation, distress tolerance, craving, and depression in patients under MMT. The present study was a randomized controlled clinical trial with two groups of intervention (MMT with Dialect-Behavioral Therapy (DBT)) and control group (MMT). Initial evaluations were performed by clinical psychiatrist at the clinic. 50 men who referred to the methadone treatment clinic were randomly assigned to two groups of the present study. The research data were collected from demographic information form, Structured Clinical Interview for Axis I Disorders, emotion regulation questionnaire, distress tolerance questionnaire, Instant craving questionnaire, and Beck Depression Inventory in three stages: pre-test, post-test and three-month follow-up. Statistical analysis was performed using Kolmogorov–Smirnov test, Lion test, Chi-square, T-test and repeated measures. The findings showed that MMT + DBT significantly improved emotion regulation and distress tolerance in post-test and 3 months follow-up, and significantly reduced craving and depression. The simultaneous combination of MMT with DBT can be helpful in reducing the psychological problems of opiate dependent people under MMT. Given the emphasis on dialectical behavioral therapy on emotion regulation as the main mechanism of change, this therapy can be a useful treatment for other psychological disorders that are involved with emotional problems.

美沙酮维持治疗（MMT）是阿片类药物依赖性疾病的常见药物治疗。这种治疗具有积极的结果，具有许多生理和心理方面的并发症。这项研究的目的是评估在MMT下，辩证行为疗法（DBT）在情绪调节，耐压，渴望和抑郁方面的有效性。本研究是一项随机对照临床试验，分为两组干预措施（MMT进行方言行为治疗（DBT））和对照组（MMT）。最初的评估是由临床精神病医生在诊所进行的。将50名到美沙酮治疗诊所就诊的男性随机分配到本研究的两组中。研究数据来自人口统计学信息表，《 I型轴心疾病的结构化临床访谈》，情绪调节问卷，痛苦容忍问卷，即时渴望问卷和贝克抑郁量表分三个阶段：测试前，测试后和三个月随访。使用Kolmogorov-Smirnov检验，Lion检验，卡方检验，T检验和重复测量进行统计分析。研究结果表明，MMT + DBT在测试后和3个月的随访中显着改善了情绪调节和痛苦承受能力，并显着减少了渴望和沮丧。MMT与DBT的同时使用可有助于减少MMT下阿片依赖者的心理问题。考虑到以情绪调节为主要机制的辩证性行为疗法的重要性，这种疗法可以有效地治疗与情感问题有关的其他心理障碍。