当前位置: X-MOL 学术Eye and Vis. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Investigation of corneal topographic and densitometric properties of Wilson's disease patients with or without a Kayser-Fleischer ring
Eye and Vision ( IF 4.2 ) Pub Date : 2021-03-11 , DOI: 10.1186/s40662-021-00231-9
Mehmet Fuat Alakus , Mehtap Caglayan , Nazım Ekin , Hasan Oncul , Esref Arac , Umut Dag , Halit Diri

To investigate the topographic measurements and densitometry of corneas in Wilson’s disease (WD) patients with or without a Kayser-Fleischer ring (KF-r) compared to healthy individuals. This cross-sectional study included 20 WD patients without a KF-r (group I), 18 WD patients with a KF-r (group II), and 20 age-matched controls (group III). The Pentacam high resolution imaging system is used to determine corneal topographic measurements and densitometry. Mean age for groups I, II and III was 25.40 ± 6.43 years (14–36 years), 25.38 ± 6.96 years (16–39 years), 23.60 ± 6.56 years (17–35 years), respectively (P = 0.623). There was no significant difference between the groups in terms of the anterior corneal densitometry values (P > 0.05), while the 6–10 mm and 10–12 mm mid stroma and the 2–6 mm, 6–10 mm, and 10–12 mm posterior corneal densitometry values in group II were significantly higher than those in groups I and III (for all values, P < 0.05). However, the 10–12 mm posterior corneal densitometry values in group I were also significantly higher than those in group III (P = 0.038). The central corneal thickness (CCT), thinnest corneal thickness (tCT), and corneal volume (CV) values in groups I and II were significantly lower than those in group III (for CCT values, P = 0.011 and P = 0.009; for tCT values, P = 0.010 and P = 0.005; for CV values, P = 0.043 and P = 0.029). In WD patients with a KF-r, corneal transparency decreased in the peripheral posterior and mid stromal corneal layers; for these patients, corneal transparency may be impaired not only in the peripheral cornea but also in the paracentral cornea.

中文翻译:

威尔森氏病患者是否有Kayser-Fleischer环的角膜地形图和光密度测量特性的研究

与健康人相比,研究威尔逊病(WD)患者中有无Kayser-Fleischer环(KF-r)的情况下角膜的地形测量和光密度测定。这项横断面研究包括20名无KF-r的WD患者(I组),18名有KF-r的WD患者(II组)和20名年龄匹配的对照组(III组)。Pentacam高分辨率成像系统用于确定角膜地形图测量值和光密度测定法。I,II和III组的平均年龄分别为25.40±6.43岁(14-36岁),25.38±6.96岁(16-39岁),23.60±6.56岁(17-35岁)(P = 0.623)。角膜前密度测定值在两组之间无显着差异(P> 0.05),中基质的6–10 mm和10–12 mm以及2–6 mm,6–10 mm,II组的角膜后密度测定值和10–12 mm显着高于I组和III组(对于所有值,P <0.05)。但是,I组的10–12 mm角膜后密度测定值也显着高于III组(P = 0.038)。I组和II组的中央角膜厚度(CCT),最薄角膜厚度(tCT)和角膜体积(CV)值均显着低于III组(对于CCT值,P = 0.011和P = 0.009;对于tCT值,P = 0.010和P = 0.005;对于CV值,P = 0.043和P = 0.029)。在患有KF-r的WD患者中,外周角膜后中层和中层角膜透明层的角膜透明度降低。对于这些患者,角膜透明性不仅会在周围的角膜中受损,而且会在中央下角膜中受损。
更新日期:2021-03-11
down
wechat
bug