The objective of the study was to evaluate anti-bacterial and anti-Inflammatory activities of polymeric microparticles. In vitro antibacterial activity was performed for prepared microparticles followed by in vivo anti-inflammatory activity on rats. From the present study, it was observed that the microparticles developed were appropriate in their shape and uniform size. The topography of SEM studies revealed that, the microparticles were smooth-surfaced. The result of antibacterial activity indicated that the formulation has not exhibited any zone of inhibition against the various strains of bacteria used for this study. The result of anti-inflammatory activity (Dextran induced paw edema) exhibits that, the formulations possess the inhibitory potential for various inflammatory mediators thereby reduces the inflammation in paws. From the results, it can be concluded that Acacia arabica microparticles is showing significant Anti-inflammatory activity after 6 h than conventional dosage form.

中文翻译：

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聚合物微粒的抗菌和消炎潜能的药理评估

该研究的目的是评估聚合物微粒的抗菌和抗炎活性。对制备的微粒进行体外抗菌活性，然后在体内进行对大鼠的抗炎活性。从本研究中，观察到所形成的微粒的形状和大小均合适。SEM研究的形貌表明，微粒是光滑表面的。抗菌活性的结果表明该制剂对本研究中使用的各种细菌菌株均未表现出任何抑制作用。抗炎活性的结果（右旋糖酐引起的爪水肿）显示，该制剂具有对多种炎性介质的抑制潜能，从而减轻了爪中的炎症。从结果可以得出结论，阿拉伯树胶微粒在6小时后显示出比常规剂型显着的抗炎活性。