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Application of Chemical Exchange Saturation Transfer (CEST) in neuroimaging
Journal of Chemical Neuroanatomy ( IF 2.8 ) Pub Date : 2021-03-11 , DOI: 10.1016/j.jchemneu.2021.101944
Kahina El Mamoune 1 , Laurent Barantin 2 , Hans Adriaensen 3 , Yves Tillet 4
Affiliation  

Since the early eighties MRI has become the most powerful technic for in-vivo imaging particularly in the field of brain research. This non-invasive method allows acute anatomical observations of the living brain similar to post-mortem dissected tissues. However, one of the main limitation of MRI is that it does not make possible the neurochemical identification of the tissues conversely to positron emission tomography scanner which can provide a specific molecular characterization of tissue, in spite of poor anatomical definition. To gain neurochemical information using MRI, new categories of contrast agents were developed from the beginning of the 2000’s, particularly using the chemical-exchange saturation transfer (CEST) method. This method induces a significant change in the magnitude of the water proton signal and allows the detection of specific molecules within the tissues like sugars, amino acids, transmitters, and nucleosides. This short review presents several CEST contrast agents and their recent developments for in vivo detection of metabolites and neurotransmitters in the brain for research and clinical purposes.



中文翻译:

化学交换饱和转移(CEST)在神经影像学中的应用

自八十年代初以来,MRI 已成为体内最强大的技术尤其是在大脑研究领域的成像。这种非侵入性方法允许对活体大脑进行急性解剖观察,类似于死后解剖组织。然而,MRI 的主要限制之一是它不能对组织进行神经化学识别,而正电子发射断层扫描扫描仪可以提供组织的特定分子特征,尽管解剖定义很差。为了使用 MRI 获得神经化学信息,从 2000 年代初开始开发新类别的造影剂,特别是使用化学交换饱和转移 (CEST) 方法。这种方法会引起水质子信号幅度的显着变化,并允许检测组织内的特定分子,如糖、氨基酸、递质、和核苷。这篇简短的回顾介绍了几种 CEST 造影剂及其最近的发展用于研究和临床目的的大脑中代谢物和神经递质的体内检测。

更新日期:2021-03-16
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